环糊精超分子聚合物在药物/基因递送载体领域的研究进展

Progress in the Application of Cyclodextrin-Based Supramolecular Polymer in Drug/Gene Delivery

超分子聚合物通常以非共价键作为构筑驱动力,其结构具有动态可逆的特点,在新型响应性聚合物材料中具有突出优势。环糊精可通过主客体识别作用与客体分子如二茂铁、偶氮苯、金刚烷、苯环等形成包合,以此构筑的超分子组装体展现出丰富的自组装-解组装特性、刺激响应性、较低的细胞毒性和较好的生物相容性,有望在药物/基因载体领域得到应用。本文从环糊精超分子聚合物的生物医用出发,着重对近年来环糊精超分子聚合物载体在药物控制释放、基因转染以及药物/基因共递送三方面的研究进展进行了总结和评述,并在此基础上展望了环糊精超分子聚合物的研究方向和发展趋势。

Noncovalent interactions are utilized as the driving force to construct supramolecular polymers（ SPs）. Due to the dynamic and reversible natures,SPs have drawn increasing attention in the field of stimuliresponsive polymeric materials. As one of host molecules, cyclodextrin can form complexes with ferrocene,azobenzene,adamantine or benzene molecules which possess the proper size through host-guest inclusion interaction.The obtained SPs display fascinating property such as stimuli-responsive property, low cytotoxicity and good biocompatibility,which may further applied in the field of drug/gene delivery. Based on the biomedical application of cyclodextrin-based SPs,the main contents are summarized including three aspects as following,cyclodextrin-based SPs used in the drug controlled release,cyclodextrin-based SPs used in the gene transfection,cyclodextrin-based SPs used in the drug/gene co-delivery. Furthermore,new research trends are also expected on the progress of this kind of SPs.