马来酸噻吗洛尔眼液联合拉坦前列素眼液对原发性开角型青光眼患者眼压的影响

Effect of Latanoprost Eeye Drops Combine with Timolol Maleate Eye Drops on Intraocular Pressure in Patients with Primary Open Angle Glaucoma

目的:探讨马来酸噻吗洛尔眼液联合拉坦前列素眼液对原发性开角型青光眼患者眼压的影响。方法:选取2015年1月-2016年5月在我院接受治疗的原发性开角型青光眼患者84例,其中给予马来酸噻吗洛尔眼液治疗的42例记为对照组,给予拉坦前列素眼液联合马来酸噻吗洛尔眼液治疗的42例记为观察组,两组均治疗6个月。对比两组患者治疗过程中的眼压变化情况,并对比两组患者的临床总有效率、药物依从性和并发症情况。结果:观察组治疗2、4、6个月后的眼压均显著低于对照组(P<0.05),观察组患者治疗6个月后与治疗前的眼压差值大于对照组(P<0.05)。两组患者治疗2、4、6个月后的眼压呈下降趋势,两两比较差异均有统计学意义(P<0.05)。观察组的临床总有效率95.24%显著高于对照组的80.95%(P<0.05)。两组患者在治疗过程中结膜充血、眼内异物感、眼睛疼痛、视力模糊、味觉异常以及总并发症发生率对比差异不显著(P>0.05)。观察组患者的药物依从性比例显著低于对照组(P<0.05)。结论:马来酸噻吗洛尔眼液联合拉坦前列素眼液治疗原发性开角型青光眼患者具有较好的临床疗效,可显著降低患者眼压,同时具有较好的安全性,但药物依从性较差。

Objective： To investigate the effect of Latanoprost eye drops combine with timolol maleate eye drops on intraocular pressure in patients with primary open angle glaucoma. Methods： 84 cases patients with primary open angle glaucoma in our hospital from January 2015 to May 2016 were selected, 42 cases were given timolol maleate eye drops treatment as the control group, 42 cases were given latanoprost eye drops combined with timolol maleate eye drops treatment as the observation group, the two groups were treated for 6 months. The intraocular pressure of two groups were compared in the course of treatment, the clinical efficacy, drug compliance and complications of the two groups were compared. Results： In the 2,4 and 6 months after the treatment, the intraocular pressure of observation group were significantly lower than the control group（P〈0.05）. The difference between before treatment and 6 months after treatment of observation group were higher than the control group（P〈0.05）. Two groups of patients after treatment for 2, 4, 6 months after the intraocular pressure showed a downward trend, the differences were statistically significant（P〈0.05）. The total effective rate of the observation group was 95.24% higher than that of the control group（80.95%）（P〈0.05）. The conjunctival congestion,intraocular foreign body sensation, eye pain, blurred vision, allotriogeusia, total complication rate of two groups were no statistical significance（P〈0.05）, the drug compliance rate of the observation group was significantly lower than that of the control group（P〈0.05）.Conclusion： Latanoprost eye drops combine with timolol maleate eye drops has good clinical efficacy in patients with primary open angle glaucoma, can significantly reduce intraocular pressure, and has better security, but the drug compliance is poor.