鼻咽癌患者放化疗前预后营养指数与预后的相关性

Correlation of pretreatment nutritional index in blood of nasopharyngeal carcinoma patients with prognosis before radiochemotherapy

目的探讨鼻咽癌患者放化疗前预后营养指数(prognostic nutritional index,PNI)与预后的关系。方法回顾性分析四川省肿瘤医院初诊鼻咽癌患者153例,收集放化疗前患者的血液学指标及临床资料并随访。用Kaplan-Meier法分析放化疗前血液学指标、PNI对鼻咽癌总生存时间的影响,进一步用Cox风险比例回归模型进行多因素分析。结果患者3、5、10年总生存率分别为89.54%、83%、75.16%。单因素及多因素分析结果提示,放化疗前PNI、白细胞计数(WBC)是鼻咽癌患者预后的独立危险因素。PNI低水平组(≤49.45)鼻咽癌患者3、5、10年总生存率低于高水平组(PNI>49.45)。结论 PNI和WBC是鼻咽癌的独立预后指标,与鼻咽癌患者的总生存时间相关。

Objective To explore the association between prognostic nutritional index（ PNI） and prognosis of nasopharyngeal carcinoma（ NPC） patients before radiochemotherapy. Methods A total of 153 newly diagnosed NPC patients in Sichuan Cancer Hospital were retrospectively reviewed. The hematological parameters and clinical characteristics before radiochemotherapy were collected,and the follow up for these patients was conducted. The effects of pretreatment hematological parameters and PNI on overall survival were analyzed with Kaplan-Meier method. The variables identified as statistically significant differences were further analyzed with multivariate Cox regression analysis. Results The 3,5 and 10-year overall survival were 89. 54%,83% and 75. 16%. Both PNI and white blood cell count（ WBC） before radiochemotherapy were the independent prognostic indicators for NPC in Cox regression analysis. The 3,5 and 10-year overall survival of NPC in PNI≤49. 45 group were lower than those of PNI 〉 49. 45 group. Conclusion PNI and WBC should be the independent prognostic indicators for NPC and closely relate to overall survival of NPC patients.