榄香烯注射液联合热疗治疗中度恶性胸腔积液临床观察

Clinical observation on the treatment of moderate malignant pleural effusion treated by elemene injection combined heat

[目的]探讨榄香烯注射液静脉点滴联合热疗治疗中度恶性胸腔积液的临床疗效。[方法]选取中度恶性胸腔积液患者80例,其中肺癌64例,乳腺癌8例,肝癌5例、卵巢癌2例、前列腺癌1例。随机分为观察组(40例),对照组(40例)。两组均予胸部高频热疗,隔日1次。观察组同期予静脉点滴榄香烯——0.4G榄香烯注射液加入0.9%氯化钠注射液250 m L中静脉点滴,每日1次,14 d为1个疗程。治疗1个疗程结束后1个月观察两组疗效、临床症状积分改善及功能状态改善情况。[结果]在客观疗效方面,观察组客观有效率(37.5%)优于对照组(17.5%),差异有统计学意义(P<0.05);两组患者在临床症状积分、生活质量方面,差异有统计学意义(P<0.05)。在不良反应方面,观察组表现为发热1例、皮肤灼伤2例,差异无统计学意义(P>0.05)。[结论]榄香烯注射液静脉点滴联合胸部高频热疗治疗中度恶性胸腔积液疗效较好,患者胸腔积液得到控制,临床症状积分降低,生活质量得到改善,无明显毒副作用,是保守治疗中度恶性胸腔积液较为理想的治疗方案。

[Objective] Explore the effect of the elemene injection combined heat therapy for the treatment of moderate malignant pleural effusion. [Methods] The 80 patients with malignant pleural effusion, including 64 cases of lung cancer, 8 cases of breast cancer, 5 cases of liver cancer, 2 cases of ovarian cancer and 1 case of prostate cancer. We randomly divided 80 meet the conditions into observation group（40 cases） and the control group（40 cases）. Both groups were given the chest high frequency heat therapy, once every other day.The observation group was given intravenous drip, 0.4 g elemene Injection and intravenous drip of 0.9% sodium chloride injection,Once daily, 14 days was a course of treatment. To observe the effects of the two groups, the improvement of clinical symptoms and the improvement of quality of life 1 month after treatment. [Results] In objective efficacy, the objective efficiency（37.5%） was better than the control group（17.5%）, and the difference was statistically significant（P〈0.05）.There were statistically significant differences between the two groups in clinical symptom points and quality of life（P〈0.05）. In the side effects, there were 1 cases of fever and 2 cases of skin burns, and there was no statistically significant difference between the two groups. [Conclusion] The elemene injection intravenous drip combined chest high frequency heat treatment effect is good, malignant pleural effusion in patients under control, integral to reduce clinical symptoms and quality of life improved, no obvious side effects, which is a moderate conservative treatment ideal treatment for moderate malignant pleural effusion.