多奈哌齐联合奥拉西坦对阿尔茨海默病患者认知功能及日常生活能力的影响

Effect of Donepezil Combined with Oxiracetam on Cognitive Function and Activity of Daily Living in Elderly Patients with Alzheimer Disease

目的探讨多奈哌齐联合奥拉西坦治疗对阿尔茨海默病患者认知功能以及日常生活能力的影响。方法选择医院2016年1月至2017年1月收治的阿尔茨海默病患者100例,采用随机数字表法分为对照组(奥拉西坦治疗)和观察组(多奈哌齐联合奥拉西坦),各50例。结果治疗1,3,6个月后,两组患者的认知功能评分均较治疗前显著提高(P<0.05),且观察组患者的认知功能评分分别为(19.54±2.09)分、(23.08±3.02)分、(25.88±1.76)分,明显优于对照组患者的(16.77±1.55)分、(19.22±1.08)分,(21.32±0.51)分(P<0.05);治疗后,两组患者日常生活能力评分和痴呆程度评分均较治疗前显著提高(P<0.05),且观察组患者日常生活能力评分与痴呆程度评分分别为(85.26±5.02)分、(40.54±2.01)分,明显优于对照组患者的(74.21±4.08)分,(43.96±2.87)分(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论多奈哌齐联合奥拉西坦治疗阿尔茨海默病,可有效提高患者认知能力以及日常生活能力,改善临床症状,有较高临床应用价值。

Objective To investigate the effect of donepezil combined with oxiracetam on the cognitive function and activity of daily living in elderly patients with Alzheimer disease（ AD）. Methods Totally 100 elderly patients with AD admitted to our hospital from January 2016 to January 2017 were randomly divided into the control group（ oxiracetam） and the observation group（ donepezil combined with oxiracetam） by the random number table method,50 cases in each group. Results After 1,3,6 months of treatment,the cognitive function scores of the two groups were higher than those before treatment（ P 〈 0. 05）, the cognitive function scores in the observation group were（ 19. 54 ± 2. 09） points,（ 23. 08 ± 3. 02） points and（ 25. 88 ± 1. 76） points, which were significantly higher than（ 16. 77 ± 1. 55） points,（ 19. 22 ± 1. 08） points and（ 21. 32 ± 0. 51） points in the control group（ P 〈 0. 05）. After treatment, the scores of activity of daily living and dementia degree in the two groups were higher than those before treatment（ P 〈 0. 05）,the scores of activity of daily living and dementia degree in the observation group were（ 85. 26 ± 5. 02） points and（ 40. 54 ± 2. 01） points,respectively,which were significantly lower than（ 74. 21 ± 4. 08） points and（ 43. 96 ± 2. 87） points in the control group（ P 〈 0. 05）. There was no significant difference in the incidence rate of adverse reactions between the two groups（ P 〉 0. 05）. Conclusion Donepezil combined with oxiracetam on in the treatment of elderly patients with AD can effectively improve the patients’ cognitive ability and activity of daily living,and improve clinical symptoms,it has high clinical application value.