心电图运动负荷血清骨保护素变化对冠心病的诊断及预后的评价

Evaluation of serum osteoprotegerin levels in diagnosis and prognosis of coronary heart in disease electrocardiogram exercise test

目的探讨心电图运动负荷试验中血清缺铁修饰骨保护素(OPG)水平变化对冠心病的诊断及病情预后的评价价值。方法选择2012年5月-2015年9月在本院行心电图运动负荷试验的患者80例,所有患者在运动前和运动后均检测血清OPG水平,运动平板试验(ETT)阳性患者进一步冠状动脉造影(CAG),探讨血清OPG水平与对冠心病的诊断价值,以及与冠心病患者冠状动脉病变程度及患者临床预后的关系。结果 CAG阳性组患者运动最大心率、运动时间明显低于CAG阴性组;运动后各时间点CAG阳性组较阴性组OPG水平升高,病变支数越多,狭窄程度越严重,患者EET后OPG水平越高。EET后6 h血清OPG水平、冠状动脉狭窄程度≥50%、冠状动脉病变支数≥2支是患者心血管事件的独立风险因素。结论心电图运动负荷试验过程中血清骨保护素有助于冠心病的诊断和患者冠状动脉病变程度的评价。

Objective To investigate the value of serum osteoprotegerin（OPG） in electrocardiogram exercise test in the diagnosis and prognosis of coronary heart disease（CHD）. Methods From July 2012 to July 2014,80 cases in our hospital underwent ECG exercise test,serum OPG levels were measured before and after exercise in all patients,and coronary angiography（CAG） was performed in exercise-tested（ETT）-positive patients to investigate the diagnostic value of serum OPG levels with coronary heart disease,and the relationship with the pathologic degree of the coronary artery and the clinical prognosis. Results The CAG positive group had significantly higher exercise heart rate and total exercise time than the CAG negative group. After exercise,the CAG positive group had higher OPG levels than the negative group. The more lesions were,the more severe the degree of stenosis was,and the higher post-EET OPG level was. EET,serum OPG levels,coronary stenosis ≥50%,and coronary lesions ≥2 after six hours were independent risk factors for cardiovascular events. Conclusion The serum osteoprotegerin during electrocardiogram exercise test is helpful for the diagnosis of coronary heart disease and the evaluation of coronary lesions in patients.