不同助孕方式治疗后肿瘤发生情况的临床观察

Clinical observation of tumor occurrence of infertile women after accepted different assisted reproductive technology

目的:探讨经体外受精–胚胎移植(IVF-ET)或宫腔内人工授精(IUI)助孕治疗后患者肿瘤发生情况。方法:回顾性分析1999年1月1日—2015年12月31日就诊于天津医科大学总医院生殖中心的患者,比较IVF/ICSI组与IUI组患者一般情况及肿瘤发生情况。结果:发现恶性肿瘤患者13例,其中IVF/ICSI组10例(0.6%),IUI组3例(0.8%),差异无统计学意义(χ~2=0.327,P=0.476);不孕年限长者(≥5年)肿瘤发生率(1.3%)明显高于不孕年限短者(0.4%)(χ~2=4.633,P=0.042);高龄患者肿瘤发生明显高于年轻患者(χ~2=11.64,P=0.01)。结论:IVF-ET较IUI助孕未增加肿瘤发生率;不孕年限长及年龄大可能为肿瘤的高危因素。

Objective：To investigate the incidence of malignant tumors of infertile women after vitro fertilization-embryo transfer （IVF-ET） or intrauterine insemination （IUI）.Methods：A retrospective study was conducted among patients with assisted reproductive technology（IVF/ICSI group and IUI group） in the reproductive center of Tianjin medical university general hospital from January 1th,1999 to December 31th,2015.The characteristics and the tumor incidences of included women were analyzed and compared between IVF/ICSI group and IUI group.Results：There were 13 women had been found malignant tumors in this study,which included 10 cases （0.6％） in IVF/ICSI group and 3 cases （0.8 ％） in IUI group.There was statistically significant differences between the two groups（x2=0.33,P =0.48）.The incidence of tumor in patients with long-term infertility （more than or equal to 5 years） was 1.3 ％,which was sig nificant higher than that of patients with short term infertility （0.4 ％）（x2=4.63,P =0.04）.The incidence of tumor in older patients was significant higher than that in young patient s （x2 =11.64,P =0.01）.Conclusion：Compared to IUI,IVF/ICSI can not increase the incidence of tumor.The long-term infertility and elder age maybe high risk factors for malignant tumors.