甲状腺上动脉血流速度在Graves病和桥本氏甲状腺炎诊断中的应用价值

Application value of blood flow velocity of superior thyroid artery in diagnosis of Graves's disease and Hashimoto's thyroiditis

目的探讨甲状腺上动脉血流速度在毒性弥漫性甲状腺肿(Graves病)和桥本氏甲状腺炎(HT)诊断中的应用价值。方法选取Graves病患者46例(Graves病组)和HT患者40例(HT组),两组患者均进行超声检查,观察两组患者甲状腺实质血流分级情况、甲状腺上动脉最大血流速度及其受试者工作特征(ROC)曲线情况。结果两组甲状腺实质血流分级情况对比差异无统计学意义(U=0.718,P>0.05)。Graves组甲状腺上动脉最大血流速度(73.42±11.53)cm/s明显大于HT组的(58.11±7.36)cm/s,差异具有统计学意义(t=7.214,P<0.05)。ROC曲线下面积0.877,最佳截断点61.7 cm/s,此时的的敏感度87.0%,特异度70.0%。结论甲状腺上动脉最大血流速度可以作为诊断Graves病和HT的重要参考指标。

Objective To discuss the application value of blood flow velocity of superior thyroid artery in diagnosis of toxic diffuse goiter （Graves＇s disease） and Hashimoto＇s thyroiditis （HT）. Methods A total of 46 patients with Graves＇s disease （Graves disease group） and 40 HT patients （HT group） all received ultrasonic examination. Observation were made on classification of thyroid parenchymal blood flow, the maximum blood flow velocity of the superior thyroid artery and its receiver operating characteristic （ROC） curve between the two groups. Results Both groups had no statistically significant difference in classification of thyroid parenchymal blood flow （U=0.718, P〉0.05）. Graves group had obviously faster maximum blood flow velocity of the superior thyroid artery as （73.42 ± 11.53） cm/s than （58.11 ± 7.36） cm/s in HT group, and their difference was statistically significant （t=7.214, P〈0.05）. The area under the ROC curve was 0.877 and the best cut-off point was 61.7 cm/s. The sensitivity at this time was 87.0% and the specificity was 70.0%. Conclusion The maximum blood flow velocity of the superior thyroid artery can be used as an important reference index for diagnosing Graves＇s disease and HT.