三维适形放射治疗联合化疗胰腺癌患者疗效分析

Analysis about three-dimensional conformal radiotherapy combined with chemotherapy in the treatment of pancreatic cancer

目的探讨三维适形放射治疗(3D-CRT)联合化疗治疗胰腺癌患者疗效及安全性。方法收集2015年2月-2017年4月我院收治的68例晚期胰腺癌患者临床资料进行回顾性分析,依据治疗方案不同分为单独采用3D-CR T的对照组和联合同期GF方案化疗的观察组,各34例,对比分析两组患者临床疗效、毒副反应、全身状况(KPS)评分及其生存期等情况。结果 (1)两组患者在性别、年龄、KPS评分、TNM分期、肿瘤部位等临床基线资料方面比较无显著差异(P>0.05)。(2)观察组总有效率显著高于对照组(P<0.05)。(3)观察组总毒副反应率虽高于对照组,但经χ2检验(P>0.05),其差异比较无统计学意义。(4)两组全身状况KPS评分情况中提高、稳定者分别比较(P>0.05),但观察组KPS评分下降者显著低于对照组(P<0.05)。(5)观察组患者6个月、12个月、中位生存期均显著高于对照组(P<0.05)。结论 3D-CRT结合化疗治疗胰腺癌患者既显著提高疗效,延缓患者全身状况急剧变差,延长生存期,也并未明显增加毒副反应,值得临床推广运用。

Objective To evaluate the efficacy and safety of three-dimensional conformal radiotherapy（3D-CRT） combined with chemotherapy in the treatment of pancreatic cancer. Methods The clinical data of 68 patients with advanced pancreatic cancer were collected from February 2015 to April 2017. Clinical data of patients with advanced pancreatic cancer were analyzed retrospectively.According to the different treatment regimens, all cases were divided into control group who was only given 3 D-CRT and observation group who was treated with concurrent chemotherapy with GF, 34 cases in each group. Clinical efficacy, the toxicity, the adverse effect, general condition score（KPS） and survival time were analyzed and compared between two groups. Results（1） There were no significant differences in gender, age, KPS score, TNM stage, tumor location and other clinical baseline data between two groups（P〉0.05）.（2）The total effective rate of the observation group was significantly higher than that of the control group（P〈0.05）.（3）The total toxicity and the side effects rate of the observation group were higher than those of the control group, but the difference was not statistically significant byχ2 test（P〉0.05）.（4） There were not significant differences in improvement and stability about KPS score of body conditions between two groups（P〈0.05）. However, the KPS score in the observation group was significantly lower than that in the control group（P〈0.05）.（5）The median survival time, 6-months survival time and 12-months survival time were significantly higher in the observation group than those in the control group（P〈0.05）. Conclusion 3D-CRT combined with chemotherapy in the treatment of pancreatic cancer patients not only can significantly improve the efficacy, delay the rapid deterioration of the patient＇s general condition, prolong survival, but also can not significantly increase the toxicity, so it is worthy of clinical application.