综合干预在青春期肥胖型多囊卵巢综合征患者中的应用

Application of Comprehensive Intervention in Puberty Obese Polycystic Ovary Syndrome

目的探讨综合干预在青春期肥胖型多囊卵巢综合征患者中的应用效果。方法选取某医院2015年1月-2016年1月期间收治的100例青春期肥胖型多囊卵巢综合征患者作为研究对象,按照随机数字表的方法分为观察组(n=50)和对照组(n=50),其中对照组仅采用达英-35进行治疗,观察组则在达英-35药物治疗的基础上联合使用二甲双胍进行治疗,并实施生活干预措施+心理治疗+健康教育,分别对两组患者干预前后的空腹胰岛素、空腹血糖、血浆性激素变化情况进行客观比较,同时比较两组患者的月经和排卵情况以及SF-36生活质量。结果观察组患者干预后的FIN、FBS改善情况明显优于干预前和对照组,差异有统计学意义(P<0.05);两组患者血浆性激素T、LH、FSH、LH/FSH经治疗后有所下降,其中观察组治疗较治疗前的下降水平更为显著(P<0.05);观察组和对照组患者的规律月经恢复率为58.00%和54.00%,排卵总体率为44.00%和46.00%,观察组优于对照组,但两组差异无统计学意义(P>0.05);此外,观察组患者的生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论综合治疗干预有助于改善胰岛素抵抗,恢复患者的正常月经周期,进而提高了患者预后的生活质量,因而值得推广。

Objective To investigate the application of comprehensive intervention in puberty obese polycystic ovary syndrome.Methods In a Hospital from January 2015 to January 2016 treated 100 cases of adolescent obesity type polycystic ovary syndrome patients as the research object,according to the random number table method divided into observation group（n=50） and control group（n=50）,the control group was treated with Diane-35,the observation group on the basis of drug treatment to the combined use of metformin,and the implementation of lifestyle intervention,psychological treatment and health education,objective to compare the changes of fasting insulin,fasting blood glucose and plasma sex hormones before and after intervention in two groups,and compare the menstrual and ovulation conditions and SF-36 quality of life between the two groups.Results By comparison,patients in the observation group after the intervention of FIN and FBS was significantly better than the control group and before intervention,significant difference（P〈0.05）; two patients plasma sex hormone T,LH,FSH,LH/FSH was decreased after treatment,the observation group under the precipitation level is more than before treatment significant（P〈0.05）; the observation group and the control group of patients with regular menstrual recovery rate was58% and 54%,44% and 46% for the overall rate of ovulation,observation group than the control group,but no significant difference between two groups（P〉0.05）.In addition,the quality of life score of the observation group was higher than that of the control group,the difference was significant（P〈0.05）.Conclusion Comprehensive treatment intervention can improve insulin resistance,resume normal menstrual cycle,and improve the quality of life in patients with prognosis.Therefore,it is worth popularizing.