IL-33/ST2信号通路在感染性疾病中的研究进展

Research progress on the role of IL-33/ST2 axis in infectious diseases

白细胞介素33(IL-33)是2005年新发现的IL-1家族细胞因子。IL-33通过与其受体肿瘤发生抑制蛋白2(ST2)特异性结合发挥生物学作用,这一过程通常被称为IL-33/ST2信号通路。在不同感染性疾病中,IL-33/ST2信号通路因病原体种类、涉及器官、感染阶段(急、慢性)和免疫微环境等不同而发挥不同的作用。本文综述了IL-33/ST2信号通路在细菌、病毒、真菌和寄生虫等所致感染性疾病中的作用。

The interleukin-33（IL-33） is a IL-1 family cytokine newly discovered in 2005, and it functions by specifically binding to its receptor suppression of tumorigenicity 2（ST2）, forming the IL-33/ST2 axis. The IL-33/ST2 axis plays different roles in different infectious diseases, depending on the type of infectious agents, organ involved, infection stage（acute or chronic）, and cellular and cytokine microenvironments. In this review, we focus on recent research progress on diverse roles of the IL-33/ST2 axis in various infectious diseases caused by bacteria,viruses, fungi and parasites.