氟西汀对老年焦虑症患者情绪和生活质量的影响

Efficacy of fluoxetine on negative emotions and quality of life in elderly patients with anxiety

目的研究氟西汀对老年焦虑症患者负面情绪和生活质量的影响。方法选取我院2016年4月~2017年4月间收治的老年焦虑症患者118例,采取随机数字法分为观察组和对照组,每组各59例。观察组患者给予氟西汀治疗,对照组患者给予丁螺环酮片治疗。比较比较两组患者治疗前后的疗效、焦虑和生活质量评分以及不良反应。结果观察组的治疗总有效率(91.53%)明显高于对照组(71.18%)(χ2=8.35,P=0.00);治疗8周后,观察组HAMA评分显著低于对照组(P<0.01),病情、体力状况、一般生活、社会心理状况、工作状况生活质量指标评分均明显高于对照组(P<0.01)。两组的不良反应发生率比较无明显差异(P>0.05)。结论氟西汀能够明显减轻老年焦虑症患者焦虑症状,提高生活质量,且治疗安全性高。

Objective To study the efficacy of fluoxetine on negative emotions and quality of life in elderly patients with anxiety. Methods A total of 118 elderly patients with anxiety in our hospital from April 2016 to April 2017 were enrolled and randomly divided into observation group （ n=59 ） and control group （ n=59 ） . Patients in the observation group were treated with fluoxetine, while the control group received buspirone. The total effective rate, the incidence of adverse reactions, the anxiety scores and quality of life scores were compared between the two groups. Results The total effective rate was significantly higher in the observation group （ 86.4 % ） than that （ 64.4 % ） in the control group （ P 〈 0.05 ） . After 8 weeks of treatment, the HAMA score of the observation group was significantly lower than those of the control group （P 〈 0.01 ） . The scores of health status, physical condition, general life, social psychological status and working status were significantly higher than those of the control group （P〈0.01） . There was no significant difference in the incidence of adverse reactions between the two groups （P 〉 0.05 ） . Conclusion Fluoxetine can obviously alleviate the symptoms of anxiety, improve the quality of life. And the treatment is safe.