中西医结合治疗阿尔茨海默病疗效的Meta分析

Clinical Efficacy of Integrated Traditional Chinese and Western Medicine in the Treatment of Alzheimer's Disease: A Meta-Analysis

目的:评价中西医结合治疗阿尔茨海默病的疗效。方法:计算机检索中国期刊全文数据库、万方数据库、中文科技期刊全文数据库、SCI数据库(web of science),搜集老年痴呆/阿尔茨海默病的随机对照试验,采用Jadad风险评价表评价其研究质量,提取资料并通过Rev Man5.2软件进行数据分析。结果:共纳入37个随机对照试验,其中对照组单独为西药的为33个,患者共计2,641例,对照组单独为中药的为4个,患者共计263例。Meta分析结果显示:中西医结合治疗阿尔茨海默病优于单一中药或西药疗法,且未见严重不良反应。结论:中西医结合治疗阿尔茨海默病优于单一疗法,可以提高临床总有效率,但安全性尚需要进一步探讨。

Objective： To evaluate the curative effect of integrated traditional Chinese and Western medicine in the treatment of Alzheimer＇s disease. Methods： The RCTs of Alzheimer＇s disease were retrieved from CNKI,Wan Fang, VIP, SCI databases. The Jadad Risk of Bias Assessment Table was used to evaluate the methodological quality of the research, and the data were ex-tracted and meta-analysed by Rev Man 5.2 software. Results：A total of 37 RCTs were included, which including 33 RCTs（2641 patients） with Western medicine as control group, and 4 RCTs（263 patients）with Chinese medicine as control group. Meta analysis showed that the efficacy of integrated traditional Chinese and Western medicine treatment of Alzheimer＇s disease was better than the single Chinese or Western medicine treatment, and there was no serious adverse reaction. Conclusion： The integrated traditional Chinese and Western medicine is better than single therapy in the treatment of Alzheimer＇s disease, which can improve the total clinical efficiency, but the safety needs to be further explored.