1540 nm非剥脱性点阵激光联合消斑酊治疗斑秃临床观察

Clinical Observation on 1540nm Non-ablative Fractional Laser Combined with Xiaoban Tincture for Alopecia Areata

目的:观察1540 nm非剥脱性点阵激光联合消斑酊治疗斑秃的临床疗效。方法:将90例斑秃患者按照随机对照法分为3组,消斑酊组予单用消斑酊外涂治疗,激光组予单用1540 nm非剥脱性点阵激光治疗,联合组予上述二者联用治疗,疗程均为8周。观察3组患者治疗前、后脱发面积的变化情况及临床疗效。结果:临床疗效总有效率联合组83.3%,消斑酊组60.0%,激光组53.3%,3组比较,差异有统计学意义(P<0.05),且联合组优于消斑酊组及激光组。治疗后,3组脱发面积均减小,且组间比较,差异均有统计学意义(P<0.05);组间两两比较,差异均有统计学意义(P<0.05),联合组优于消斑酊组及激光组。3组患者均无全身不良反应。结论:1540 nm非剥脱性点阵激光联合消斑酊治疗斑秃疗效要优于单纯使用激光或消斑酊治疗。

Objective： To observe the clinical effect of 1540 nm non-ablative fractional laser combined with Xiaoban tincture for alopecia areata. Methods： Divided 90 cases of patients with alopecia areata into three groups according to randomized controlled method. The Xiaoban tincture group was treated with simple Xiaoban tincture,while the laser group was treated with simple 1540 nm non-ablative fractional laser, and the combination group was treated with the combined treatment of the above two groups. The treatment of the three groups lasted for eight weeks. Observed the changes of alopecia area and clinical effect in the three groups before and after treatment. Results： The total effective rate of clinical effect was 83.3% in the combination group, 60.0% in the Xiaoban tincture group and 53.3% in the laser group,the difference being significant（P〈0.05）. The clinical effect in the combination group was superior to that in the Xiaoban tincture group and the laser group. After treatment,alopecia area of the three groups decreased;when compared alopecia area between the three groups,differences were significant（P〈0.05）. The differences between any two groups were statistically significant（P〈0.05）. The decrease of alopecia area of the combination group was better than that of the Xiaoban tincture group and the laser group. No adverse reaction was found in the three groups. Conclusion： The therapy of 1540 nm non-ablative fractional laser combined with Xiaoban tincture for alopecia areata is superior to that of simple treatment of laser or Xiaoban tincture.