检测肺癌患者血清p53抗体的临床意义

Clinical Significance of Detecting Serum p53Antibody in Lung Cancer Patients

目的:探讨检测肺癌患者血清p53抗体的临床意义。方法:采用酶联免疫吸附法检测120例肺癌患者血清p53抗体,并以30例肺部良性疾病患者和120例正常健康人作对照。结果:肺癌患者血清p53抗体水平明显高于肺部良性疾病患者和正常人(P<0.05),而正常人与肺部良性疾病患者间无显著性差异(P>0.05)。120例肺癌中26例p53抗体阳性,阳性率为21.7%,而30例肺部良性疾病患者和120例正常人无1例阳性。肺癌者血清p53抗体与肺癌细胞分化程度和临床分期有密切关系(P<0.01)。结论:检测血清p53抗体水平有助于肺部良恶性疾病的诊断及鉴别诊断。

Objective:To explore the clinical significance of detecting serum p53antibody in patients with lung cancer.Methods:Serum p53antibody were detected in120patients with lung cancer,30patients of them with benign pulmonary disease and120healthy individuals as control using enzyme linked immunosorbent assay.Results:The level of serum p53antibody in patients with lung cancer was significantly higher than that in patients with benign pulmonary disease and normal controls(P<0.05),but there was no significant difference between the patients with benign pulmonary disease and the normal individuals(P>0.05).Of the120patients with lung cancer21.7%(26/120)were positive for serum p53antibody,but all the30patients with benign pulmonary disease and120normal individuals were negative.The level of serum p53antibody in patients with lung cancer were closely related to cell differentiation and stage of lung cancer(P<0.01).Conclusion:Detection of serum p53antibody is helpful to differentiate the diagnosis of benign and malignant pulmonary diseases and to monitor the proceeding of lung cancer