痰热清注射剂体外配伍文献评价

Literature Evaluation on in Vitro Compatibility of Tanreqing Injection

目的探讨痰热清注射剂与其他药物的配伍禁忌,以及在溶剂中的稳定性。方法通过计算机检索中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、中文科技期刊数据库(VIP)及万方数据库,检索时间截至2016年7月。经过文献筛选,资料提取,并按照自定义的方法学质量评价标准进行评价,统计配伍反应结果。结果共获取痰热清注射剂与其他药物配伍的体外试验研究、个案报道等共5 670篇,经过筛选后纳入143篇;从实验药物及其配置、配伍药物及其配置、观察时间、检测方法、结果描述等方面进行方法学质量评价,存在的主要问题为对配置浓度描述不清或配置不当;痰热清注射剂与常规溶剂均存在配伍问题,主要表现为微粒数增加超过标准,与常用的头孢菌素类、喹诺酮类、氨基苷类等抗菌药物,与茶碱类、维生素类、制酸类药物等配伍可出现沉淀或浑浊。结论痰热清注射剂不宜与抗菌药物、茶碱类、维生素类、制酸类药物等配伍使用,接续静脉滴注前后应冲管。由于大部分配伍结果来源于少数研究报道,因此结果仍需作一步证实。

Objective To investigate the incompatibility of Tanreqing Injection with other drugs and its stability in solvents.Methods The literatures about the in vitro compatibility of Tanreqing Injection were searched from CNKI,CBM,VIP,Wanfang database until July 2016. After literatures screening and data extraction, the data were evaluated according to the customizable methodological quality evaluation criteria,and results of compatibility were statistically analyzed. Results Totally 5670 studies and case reports of in vitro compatibility of Tanreqing Injection with other drugs were conducted,after screening,143 articles were included. The quality of the methodology was evaluated from the aspects of the drug and its configuration, the compatibility of the drug and its configuration, the time of observation,the method of detection,and the description of the results. The main problem was that the description of the configuration concentration was not clear or the configuration was improper. There was a compatibility problem when Tanreqing Injection dissolved in conventional solvents, the number of particles increased and exceeded than the standard. Moreover, cephalosporin, quinolones,aminoglycosides, theophylline, vitamins, and anti-acid drugs could precipitate or turbid when mixed with Tanreqing Injetion.Conclusion Tanreqing Injection should not be mixed with antibiotics,theophylline,vitamins and acid producing drugs. In addition,when Tanreqing Injection continuous intravenous infusion with these drugs, the tube should be rinsed. As the limited quantity of included studies,the conclusion need to be further confirmed.