肠道菌群与心血管疾病相关性的研究进展

Research progress on correlation between intestinal flora and cardiovascular diseases

肠道菌群是调节宿主代谢活动及调控肠道免疫屏障和生物屏障的重要微生物群,与心血管疾病联系密切。肠道菌群紊乱可破坏机体正常代谢,增强体内氧化应激反应,并通过内毒素移位到体循环而加剧全身性炎症,是心血管疾病发生、发展的重要因素之一。而心血管疾病患者血流动力学的变化可进一步改变其肠道的形态、功能以及肠道菌群组成,从而造成疾病恶化。该文通过检索、梳理近16年国内外相关文献,综述肠道菌群与心血管疾病的相互作用机制,以及通过肠道菌群治疗心血管疾病的可能方法,为通过干预肠道菌群治疗心血管疾病提供理论依据和策略参考。

The variation in the hemodynamics of patients with cardiovascular diseases can change intestinal morphology,intestinal permeability,intestinal barrier function and intestinal flora composition. The changes can further damage the intestinal tract,resulting in intestinal flora disorders,metabolic destruction,enhancement of oxidative stress and exacerbation of systemic inflammation. Meanwhile,metabolites via intestinal flora also have a possible regulatory mechanism for the pathophysiology of cardiovascular diseases. In the review,the relevant literatures in recent 16 years concerning the interactive relationship between intestinal flora and cardiovascular diseases and treatment of cardiovascular diseases through intestinal flora have been collected,in order to provide a theoretical reference for treatment of cardiovascular diseases via intestinal flora.