艾灸对恶性肿瘤患者免疫功能影响的Meta分析

Meta analysis for moxibustion on the immune function of patients with malignant tumor

目的运用循证医学方法评价艾灸对恶性肿瘤患者免疫功能的影响。方法通过对中国生物医学文献数据库、中国知网、维普数据库、万方数据库的检索,对符合要求的RCT文献进行Meta分析。结果纳入13个临床试验,共计978例患者,对免疫球蛋白[免疫球蛋白G(Ig G)、免疫球蛋白A(Ig A)、免疫球蛋白M(Ig M)]、免疫细胞[CD3、CD4、CD8和自然杀伤细胞(NK细胞)]、红细胞C3b受体(Rbc-C3bR)花环的形成率、白细胞介素-2(IL-2)等9项免疫指标进行Meta分析,其中CD3、CD4、Ig G、Ig A、Rbc-C3bR花环的形成率、IL-2等6项指标与对照组相比,差异有统计学意义;Ig M、CD8和NK的Meta分析结果显示差异无统计学意义。结论艾灸在一定程度上可以提高肿瘤患者的免疫功能,但还需要更多的研究数据支持。

Objective To evaluate the effect of moxibustion on the immune function of patients with malignant tumor by using the method of evidence-based medicine. Methods Meta-analysis was performed on the RCT literatures that meet the requirements by searching the Chinese Biomedical Literature Database,China Knowledge Network,VIP Database and Wanfang Database. Results A total of 978 patients were enrolled in 13 clinical trials. The meta-analysis of nine immune indicatorswere analyzed,which included the immunoglobulin（ Ig G,Ig A,Ig M）,the immune cells（ CD3,CD4,CD8 and NK cells）,the formation rate of erythrocyte Rbc-C3 bR rosette and IL-2. The results of the meta-analysis showed that the indicators of CD3,CD4,Ig G,Ig A,the rate of Rbc-C3 bR rosette formation and IL-2 for the patients in the clinical trials were significantly different from those in the control group. The results of the meta-analysis also showed that compared with the indicators of Ig M,CD8 and NK for the patients in the control group,these indicators of the patients in the clinical trials,were not statistically significant. Conclusion Moxibustion can improve the immune function of patients with malignant tumor to a certain extent,but more research data are needed to support such results.