川芎茶调散合苍耳子散联合西医常规疗法治疗急性鼻窦炎临床研究

Chuanxiong-Chatiao powder and Cangerzi powder combined with routine treatment for acute rhinosinusitis

目的 评价川芎茶调散合苍耳子散联合西医常规疗法治疗急性鼻窦炎（acute rhinosinusitis, ARS）的疗效。方法 将符合入选标准的104例ARS患者采用随机数字表法分为2组，每组52例。对照组以控制感染和对症处理为主，采用西医常规疗法治疗；治疗组在对照组治疗基础上配合川芎茶调散合苍耳子散加减治疗。2组均连续治疗1个月，随访6个月。对2组治疗前后症状总分量表（total symptom score, TSS）进行评分，记录鼻塞、鼻涕、头昏痛和鼻腔分泌物改善时间，评价临床疗效；随访6个月，记录复发率。结果 治疗后，治疗组TSS总评分[（3.9±0.5）分比（5.9±0.6）分，t＝-18.466]低于对照组（P＜0.01）；鼻塞、鼻涕、头昏痛和鼻腔分泌物缓解时间均较对照组缩短（t值分别为5.367、8.034、-7.525、-6.757，P＜0.01）；治疗组总有效率为86.5%（45/52）、对照组为69.2%（36/52），2组比较差异有统计学意义（χ2＝4.522，P＝0.034）。随访6个月，治疗组复发率为11.4%（4/35）、对照组为33.3%（9/27），2组比较差异有统计学意义（χ2＝4.413，P＝0.036）。结论 川芎茶调散合苍耳子散联合西医常规疗法可有效缓解ARS患者症状、体征，提高临床疗效，降低复发率。

Objective To evaluate the efficacy of Chuanxiong-Chatiao powder and Cangerzi powder combined with routine treatmentfor the patients with acute rhinosinusitis. Methods A total of 104 patients with acute rhinosinusitis were enrolled and divided into the treatment group （52 patients） and the control group （52 patients） by random number table method. Patients in the control group were treated with routine treatment of western medicine, while those in the treatment group with Chuanxiong-Chatiao powder and Cangerzi powder plus routine treatment of western medicine. All the treatments lasted 30 days, with follow-up of 6 months. The total symptom scores （TSS）, nasal obstruction, nasal discharge, dizziness, and nasal secretion improvement time, and the clinical curative effect of the two groups were observed and recorded. Results The total effective rate in the treatment group was significantly higher than that in the control group [86.5% （45/52） vs. 69.2% （36/52）; χ2=4.522, P=0.034]. After treatment, the TSS of the treatment group were significantly lower than the control group （3.9 ± 0.5 vs. 5.9 ± 0.6; t=18.466, P〈0.01）. The nasal obstruction, nasal discharge, dizziness, and nasal secretion improvement time in the treatment group was superior to those in the control group （t were 5.367, 8.034, -7.525 ,-6.757, P〈0.01）. In the follow-up of 6 months, the recurrence rate in the treatment group was significantly higher than that in the control group [33.3% （9/27） vs. 11.4% （4/35）; χ2=4.413, P=0.036]. Conclusions Chuanxiong-Chatiao powder and Cangerzi powder combined with routine treatment can improve the clinical symptoms in patients western medicine with acute rhinosinusitis.