柴胡加龙骨牡蛎汤加减治疗失眠肝郁化火证40例临床观察

Clinical effect of modified Chaihu Longgu Muli decoction in treatment of insomnia with liver depression transforming into fire: An analysis of 40 cases

目的:观察柴胡加龙骨牡蛎汤加减联合艾司唑仑治疗失眠肝郁化火证的临床疗效。方法:将80例失眠肝郁化火证患者随机分为2组各40例。对照组给予艾司唑仑口服治疗,治疗组在对照组治疗的基础上结合柴胡加龙骨牡蛎汤加减治疗,疗程均为20d,观察比较2组综合疗效及PSQI评分与中医证候评分。结果:总有效率治疗组为92.5%,对照组为67.5%,组间比较,差异有统计学意义(P<0.05);2组PSQI评分、中医证候评分治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.05)。结论:柴胡加龙骨牡蛎汤加减联合艾司唑仑治疗失眠肝郁化火证具有较好的临床疗效。

Objective： To investigate the clinical effect of modified Chaihu Longgu Muli decoction combined with estazolam in the treatment of insomnia with liver depression transforming into fire. Methods： A total of 80 patients with insomnia with liver depression transforming into fire were randomly divided into treatment group and control group,with 40 patients in each group. The patients in the control group were given oral estazolam,and those in the treatment group were given modified Chaihu Longgu Muli decoction in addition to the treatment in the control group. The course of treatment was 20 days for both groups,and the two groups were compared in terms of overall response,Pittsburgh Sleep Quality Index（PSQI） score,and traditional Chinese medicine（TCM） syndrome score. Results： There was a significant difference in overall response rate between the treatment group and the control group（92. 5% vs 67. 5%,P〈0.05）. Both groups had significant changes in PSQI score and TCM syndrome score after treatment,and there were significant differences in these scores between the two groups after treatment（P〈0.05）. Conclusion： Modified Chaihu Longgu Muli decoction combined with estazolam has a good clinical effect in the treatment of insomnia with liver depression transforming into fire.