新生儿肺炎诊治中监测降钙素原水平的临床价值研究

Clinical Value of Monitoring of Procalcitonin Levels in the Diagnosis and Treatment of Neonatal Pneumonia

目的探析在新生儿肺炎诊断中检测降钙素原水平的临床价值。方法方便选取该院2012年10月—2016年10月期间收治的150例新生儿,其中100例为新生儿肺炎患儿,根据感染的程度分为轻症组(n=50)和重症组(n=50),另50名新生儿为正常健康新生儿,作为对照组,分别检测3组新生儿的降钙素原水平,并进行统计比较PCT结果。结果重症组患儿的PCT水平(11.57±6.21)ng/m L,显著高于轻症组(1.23±0.24)ng/m L和对照组(0.91±0.21)ng/m L,比较差异有统计学意义(t=4.72,4.08,P<0.05);恢复期重症组PCT水平(1.01±0.14)ng/m L与治疗前(11.57±6.21)ng/m L比较显著降低(t=4.792,P<0.05)。结论在新生儿肺炎诊断中检测降钙素原水平,可作为早期诊断的标准,临床价值好,值得临床推广。

Objective This paper tries to explore the clinical value of detecting procalcitonin levels in the diagnosis of neonatal pneumonia. Methods 150 neonates admitted to the hospital from October 2012 to October 2016 were convenient selected. Among them, 100 were neonates with pneumonia. They were divided into mild group（n=50） and severe group（n=50） according to the degree of infection, the other 50 neonates were normal healthy newborns as the control group, the levels of procalcitonin were measured in the three groups of neonates, and statistical comparisons of PCT results were performed.Results The PCT level in children with severe disease（11.57±6.21） ng/m L was significantly higher than that in mild group（1.23±0.24） ng/m L and control group（0.91±0.21） ng/m L, and the difference was statistically significant（t=4.72, 4.08,P〈0.05）;The PCT level（1.01±0.14） ng/m L in the critically ill group was significantly lower than that before the treatment（11.57±6.21） ng/m L（t=4.792, P〈0.05）. Conclusion The detection of procalcitonin level in the diagnosis of neonatal pneumonia can be used as a standard for early diagnosis. It has good clinical value and is worthy of clinical promotion.