老年不稳定性心绞痛血清N端脑钠肽前体和β_2微球蛋白表达的分析

Analysis of serum NT-proBNP and β_2-MG in elderly patients with unstable angina

目的探讨老年不稳定性心绞痛(UA)患者血清N端脑钠肽前体(NT-proBNP)和β_2微球蛋白(β_2-MG)在危险分层中的表达情况以及血清NT-proBNP和β_2-MG的相关性分析。方法纳入100例年龄在60岁以上老年不稳定性心绞痛患者,按照危险分层分为3组:低度危险组、中度危险组和高度危险组,进行血清NT-proBNP和β_2-MG检测。结果高度危险组血清NT-proBNP和β_2-MG水平显著高于中度危险组和低度危险组,中度危险组血清NT-proBNP和β_2-MG显著高于低度危险组(P<0.05)。血清NT-proBNP、β_2-MG水平均与年龄呈正相关(r值分别为0.347、0.444,P<0.01)。血清NT-proBNP水平与β_2-MG水平呈正相关(r=0.489,P<0.01)。结论血清NT-proBNP和β_2-MG水平升高与老年不稳定性心绞痛密切相关,可灵敏地反应老年不稳定性心绞痛患者的病情程度。

Objective To investigate the expressions of serum N-terminal pro-brain natriuretic peptide（NT-proBNP） andβ_2 microglobulin（β_2-MG） in risk stratification and the correlation between serum NT-proBNP and β_2-MG in elderly patients with unstable angina pectoris（UA）. Methods A total of 100 patients with unstable angina pectoris aged 60 years and older were divided into three groups according to risk stratification： low risk group,moderate risk group and high risk group.Serum NT-proBNP and β_2-MG were detected. Results Compared with moderate risk group and low risk group,the serum levels of NT-proBNP and β_2-MG in high risk group were significantly higher. Compared with low risk group,the serum levels of NT-proBNP and β_2-MG in moderator risk group were significantly higher（P〈0. 05）. Serum NT-proBNP and β_2-MG levels were positively correlated with age（r = 0. 347,r = 0. 444,P〈0. 01）. Serum NT-proBNP levels were positively correlated with β_2-MG levels（r = 0. 489,P〈0. 01）. Conclusion Elevated levels of serum NT-proBNP and β_2-MG are closely related to unstable angina in the elderly,and can be sensitive to the severity of senile unstable angina patients.