摘要
精子DNA碎片(SDF)是近年来国内外生殖医学领域研究的热点,随着大量实验研究和临床研究的开展,SDF对于男性生殖能力具有重大影响已成为学术界的共识。但是,SDF产生机制不明确,治疗手段也较为有限,同时关于SDF的众多问题仍然存在较大争议,本文从SDF的产生机制、临床意义、检测方法和治疗手段4个方面对SDF的发展及应用现状予以综述,以利于对SDF进一步的深入研究。
Sperm DNA fragmentation is a hot spot in the field of reproductive medicine at home and abroad recently.With the development of a large number of experimental studies and clinical researches,the significant impact of the SDF on male reproductive ability has become the consensus of academia.Nonetheless,there are many controversial issues on the SDF.Its exact mechanism is unclear,and its effective cure methods are comparatively limited.In this paper,we reviewed basic experiments and clinical trials to contribute to its in-depth studies from four aspects the generation mechanism of SDF,clinical significances,detection methods and treatment methods.
作者
张俊峰
彭炜
王涛
刘继红
ZHANG Junfeng;PENG Wei;WANG Tao;LIU Jihong(Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China;Hubei Institute of Urology)
出处
《临床泌尿外科杂志》
2018年第8期669-674,共6页
Journal of Clinical Urology
关键词
精子DNA碎片
产生机制
临床意义
检测方法
治疗手段
sperm DNA fragmentation
mechanism theory
clinical significance
detection method
treatment method
