摘要
以最常见的芳基乙酮为原料,经二氧化硒氧化得到相应芳基酮酸,在氯化亚砜氯化后直接与不同的胺反应得到一系列芳基酮酰胺,接着与磺酰胺加成得到关键中间体α-磺酰亚胺芳基酰胺,最后还原得到目标产物α-磺酰胺芳基酰胺。合成路线具有原料易得、操作方便、收率较高等优点,其结构经1HNMR、13CNMR、高分辨质谱、红外和熔点等手段表征。该产物可用于生物活性物质的合成中。
The aryl ketonic acid were prepared readily via oxidation reaction of substitutional acetophenones and subsequent chlorination and amination to afford the corresponding aryl keto-amides.The key intermediates α-sulfimide aryl amides were coupled with sulfamide.A series of α-sulfamide aryl amides were obtained with good yields after reduction.The structures were characterized by 1HNMR,13CNMR,HR-MS,IR and melting point measurement.The aminoamide products could subsequently be used in the synthesis of bioactive compounds.
作者
李飞龙
胡雅雯
王玉麟
赵敏
陈建中
LI Fei-long;HU Ya-wen;WANG Yu-lin;ZHAO Min(School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shang-hai 200237,China;School of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China)
出处
《化学试剂》
CAS
北大核心
2018年第9期823-830,共8页
Chemical Reagents
