无抽搐电休克治疗合并药物与单纯药物治疗双相情感障碍躁狂相的临床对照研究

Clinical Comparative Study on Modified Electroconvulsive Therapy Combined with Drugs or Drugs Alone in the Treatment of Manic Phase of Bipolar Disorder

目的探讨无抽搐电休克治疗(MECT)合并药物与单纯药物治疗双相情感障碍躁狂相的临床效果。方法选取我院2016年1月至2018年1月收治的64例双相情感障碍躁狂相患者,随机分为对照组和试验组各32例。两组患者入院后均给予相同药物治疗,试验组增加MECT治疗。对比两组患者的临床疗效、起效时间、住院时间及应激反应指标。结果治疗前,两组患者的BPRS、 BRMS评分及应激反应指标比较均无统计学差异(P>0.05);治疗后,试验组的BPRS、 BRMS评分均低于对照组,CAT、 GSH-Px、 MDA水平均低于对照组, SOD水平高于对照组,差异有统计学意义(P <0.05)。试验组的起效时间和住院时间均短于对照组(P <0.05)。结论 MECT合并药物治疗双相情感障碍躁狂相可显著提高临床效果,改善患者的应激反应指标,缩短其住院时间,值得临床推广。

Objective To explore the clinical effect of modified electroconvulsive therapy（MECT） combined with drugs or drugs alone in the treatment of manic phase of bipolar disorder. Methods 64 cases of patients with manic phase of bipolar disorder admitted to our hospital from January 2016 to January 2018 were selected and divided into control group and experimental group randomly, with 32 cases in each group. Both groups were treated with the same drug after admission, and the experimental group received MECT on this basis. The clinical efficacy, onset time, hospitalization time and indicators of stress response were compared between the two groups. Results Before treatment, no statistical difference was found in the BPRS and BRMS scores and indicators of stress response between the two groups（P0.05）. After treatment, the BPRS and BRMS scores of the experimental group were lower than those of control group, the CAT, GSH-Px and MDA levels were lower than those of control group, and the SOD level was higher than that of the control group（all P 0.05）. The onset time and hospitalization time of the experimental group were shorter than those of the control group（P 0.05）. Conclusions MECT combined with drugs in the treatment of manic phase of bipolar disorder can significantly improve the clinical effect, improve the indicators of stress response, and shorten the hospitalization time, which is worthy of clinical promotion.