摘要
香豆素类抗凝药——华法林是临床上最广泛使用的口服抗凝药物之一,通常用于预防和治疗血栓栓塞性疾病,但由于该药治疗窗狭窄,用药剂量和疗效个体差异大,因此在临床应用中需要个体化给药。文章就导致华法林临床维持剂量变异的CYP2C9、VKORC1、GGCX、CYP4F2以及ApoE基因多态性作一综述,通过对基因频率以及维持剂量的分析、总结,以期为华法林临床安全、合理使用提供指导。
Warfarin, one of the most commonly prescribed oral coumarin anticoagulants, is widely used in the prevention and treatment of thromboembolic diseases.Due to the narrow thera peutic window and the large inter individual and intra individual variability in dose response,indi vidualized warfarin dosing strategies are necessary in clinical practice. In this review, we summa rize genetic polymorphisms in CYP2C9, VKORC1, GGCX, CYP4F2 and ApoE, which are factors associated with clinical variability in warfarin maintenance dose. Based on dosing algorithms and genotype analysis, our goal is to provide an optimal individualized dosing strategy for safe and ra tional use of warfarin.
作者
于洋
何佳珂
熊爱珍
夏春华
YU Yang;HE Jia-ke;XIONG Ai-zhen;XIA Chun-hua(Institute of Clinical Ptzarmacology,Nanctzang University,Nanctzang 330006,Ctzina;Department of Ptzarmacy,ttze Second Affiliated Hospital of Nanctzang Uniwersity,Nanckang 330006,Ckina)
出处
《南昌大学学报（医学版）》
CAS
2018年第4期77-80,共4页
Journal of Nanchang University：Medical Sciences
基金
国家自然科学基金(81603188)
江西省自然科学基金(20151BAB215041)
江西省教育厅科学技术研究项目(GJJ170156)
南昌大学第二附属医院基金(2014YNQN2001)
关键词
华法林
基因多态性
维持剂量
个体化给药
合理用药
warfarin
genetic polymorphisms
maintenance dose
individualized medication
rational drug use
