血管性痴呆并H型高血压采用依那普利叶酸片的治疗效果

Effect of Enalapril Folic Acid Tablets on H-type Hypertension With Vascular Dementia

目的观察研究血管性痴呆并H型高血压患者接受依那普利叶酸片的临床疗效情况。方法选择的研究对象为在本院接受治疗的血管性痴呆并H型高血压患者,共计为68例,选取时间均为2016年2月—2017年4月之间。利用随机数字表格法分组,均分为观察组34例和对照组34例。对照组服用依那普利片,观察组服用依那普利叶酸片,分析两组患者治疗半年后的血清同型半胱氨酸、平均动脉压以及MMSE分数变化情况。结果治疗后两组的血清Hcy以及平均动脉压均显著较治疗前降低,而观察组中Hcy显著低于对照组(P <0.05),平均动脉压组间无显著差异(P> 0.05)。在治疗后阶段,两组MMSE分数均发生升高,而观察组分数显著高于对照组(P<0.05)。结论临床上采用依那普利叶酸片治疗血管性痴呆伴H型高血压能够获得较好的效果,治疗后血压水平以及Hcy均获得改善,同时其精神状态显著提升,临床价值高。

Objective To observe the clinical effect of enalapril folate tabletsin patients with vascular dementia and H type hypertension. MethodsA total of 68 patients with vascular dementia and H type hypertensionwere selected from February 2016 to April 2017. They were divided intoobservation group （n = 34） and control group （n = 34）. The control grouptook enalapril tablets and the observation group took enalapril folic acidtablets. The changes of serum homocysteine, mean arterial pressure andMMSE score were analyzed in the two groups after six months of treatment.Results after treatment, the serum Hcy and mean arterial pressure in thetwo groups were significantly lower than those before treatment, while the Hcy in the observation group was significantly lower than that inthe control group （P 〈 0.05）, but there was no significant differencein mean arterial pressure between the two groups （P 〉 0.05）. Aftertreatment, the MMSE scores of the two groups were increased, whilethe scores of the observation group were significantly higher thanthose of the control group （P 〈 0.05）. Conclusion Enalapril folic acidtablet is effective in the treatment of vascular dementia with H typehypertension. After treatment, the level of blood pressure and Hcyare improved, and its mental state is significantly improved, and itsclinical value is high.