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骨苓通痹丸联合双氯芬酸钠肠溶片对激素性股骨头坏死肾虚血瘀证患者的临床疗效 被引量:11

Clinical effects of Guling Tongbi Pills combined with Diclofenac Sodium Enteric-coated Tablets on steroid-induced osteonecrosis of femoral head patients due to Kidney Deficiency and Blood Stasis Pattern
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摘要 目的探讨骨苓通痹丸联合双氯芬酸钠肠溶片对激素性股骨头坏死肾虚血瘀证患者的临床疗效。方法将147例(217髋)患者随机分为骨苓通痹丸组、双氯芬酸钠肠溶片组和联合组,每组49例,疗程均为2个月。然后,记录Harris、SF-36评分,以及髋关节疼痛、X光片、骨密度、中医证候积分,测定全血高切还原黏度(BHRV)、全血低切还原黏度(BLRV)、血浆黏度(PV)、血细胞比容(HCT)、血清超氧化物歧化酶(SOD)、C反应蛋白(CRP)、一氧化氮(NO)、白细胞介素-1β(IL-1β),比较总有效率、复发率、不良反应发生率。结果与其他2组比较,联合组总有效率显著更高(P <0. 05),Harris、SF-36评分,髋关节疼痛、X光片、骨密度、中医证候积分,BHRV、BLRV、PV、HCT、SOD、CRP、NO、IL-1β改善程度显著更优(P <0. 05)。各组不良反应发生率依次为骨苓通痹丸组<联合组<双氯芬酸钠肠溶片组,复发率依次为联合组<骨苓通痹丸组<双氯芬酸钠肠溶片组,差异均有统计学意义(P <0. 05)。结论骨苓通痹丸联合双氯芬酸钠肠溶片治疗激素性股骨头坏死肾虚血瘀证患者时,具有增效减毒的作用。 AIM To explore the clinical effects of Guling Tongbi Pills combined with Diclofenac Sodium Enteric-coated Tablets on steroid-induced osteonecrosis of femoral head patients due to Kidney Deficiency and Blood Sta- sis Pattern. METHODS One hundred and forty-seven patients (217 hips) randomly assigned to the groups, 49 cases in each group, for the respective 2-month intervention of Guling Tongbi Pills, or Diclofenac Sodium Enteric- coated Tablets, or the combination therapy, were assessed with Harris and SF-36 scores, scale of hip joint pain, X- ray film, bone density, TCM syndrome integrals, and their reduction in values of whole blood viscosity at high- shear (BHRV) and low-shear rates ( BLRV), plasma viscosity (PV), hematocrit ( HCT), superoxide disnmtase (SOD), C-reactive protein (CRP), nitric oxide (NO) and interleukin-1β (IL-1β) by biomarkers were deter- mined. The cross-sectional comparison of total effective rates, recurrence rates and adverse reaction incidence rates were made among the three groups. RESULTS Compared with the other two groups, the combination group demonstrated significantly higher total effective rate (P 〈 0.05 ) , in addition to markedly better improvement in Harris and SF-36 scolds, hip joint pain scale, X-ray film, bone density, TCM syndrome integrals, and BHRV, BLRV, PV, HCT, SOD, CRP, NO, IL-1β (P 〈 0.05). The sequence of adverse reaction incidence rates in various groups was the Guling Tongbi Pills group 〈 the combination group 〈 the Diclofenac Sodium Enteric-coated Tablets group, that of recmTence rates was the combination group 〈 the Guling Tongbi Pills group 〈 the Diclofenac Sodium Enteric-coated Tablets group. All the differences were statistically significant (P 〈 0.05 ). CONCLUSION For patients with steroid-induced osteonecrosis of femoral head due to Kidney Deficiency and Blood Stasis, the combina- tion use of Guling Tongbi Pills and Diclofenac Sodium Enteric-coated Tablets exhibits efficacy enhancing and toxicity reducing effect.
作者 杜敏 汪利合 王平 武凤玲 谷慧敏 DU Min;WANG Li-he;WANG Ping;WU Feng-ling;GU Hui-min(The Second Hospital Affiliated to Henan University of Chinese Medicine,Zhengzhou 450002,China;The First Hospital Affiliated to Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处 《中成药》 CAS CSCD 北大核心 2018年第10期2144-2149,共6页 Chinese Traditional Patent Medicine
基金 河南省教育厅科学技术研究重点项目指导计划项目(14B360018)
关键词 骨苓通痹丸 双氯芬酸钠肠溶片 激素性股骨头坏死 肾虚血瘀证 Guling Tongbi Pills Diclofenac Sodium Enteric-coated Tablets steroid-induced osteonecrosis of femoral head Kidney Deficiency and Blood Stasis Pattern
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