低氧诱导因子在肿瘤中的表达

Hypoxia-Inducible Factor and Tumor

低氧诱导因子(Hypoxia-Inducible Factors,HIFs)是一类介导细胞适应低氧应激反应的调控因子,是细胞适应缺氧的主要驱动力。HIFs在多种癌细胞中高表达,转录调控大量基因表达,从而增强癌细胞对肿瘤恶性微环境的适应力,参与肿瘤的发生与发展进程。目前,HIFs已经成为新型癌症治疗药物的靶点。本文对低氧诱导因子参与肿瘤的血管生成、代谢、增殖以及相关的靶基因等方面进行了阐述。

Hypoxia-Inducible Factors （HIFs） are stress and are the main driving force for cells to adapt a class of regulators that mediate cellular adaptation to hypoxia to hypoxia. HIFs are highly expressed in a variety of cancer cells, and transcriptionally regulate a large number of gene expression, thereby enhancing the adaptability of cancer cells to the malignanl t microenvironment of tumors, and participating in the occurrence and development of tumors. At present, HIFs have become the target of new cancer therapeutic drugs. This review covers the involvement of hypoxia-inducible factors in tumor angiogenesis, metabolism, proliferation, and their related target genes.