96例慢性肾脏疾病患者血清中Ccr和BNP、hs-cTnI的水平分析

Analysis of serum levels of Ccr and BNP and hs-cTnl in 96 patients with chronic kidney disease

目的：探讨慢性肾脏疾病患者中内生肌酐清除率（Ccr）和B型利钠肽（BNP）、超敏肌钙蛋白I（hs—cTnI）中的关系及其对患者预后的预测价值。方法：选择本院’肾内科慢性肾脏疾病96例住院患者作为研究对象，健康体检者40例作为对照组。采用雅培C16000仪器测定血清中肌酐（Cr）值并计算出内生肌酐清除率（Ccr），采用雅培12000测定hs-cTnI和B型利钠肽的浓度。结果：在慢性肾脏疾病患者中，BNP的浓度随着Ccr的降低而升高，hs-cTnI也有部份升高。BNP和hs—cTnI同时升高，对患者的预后评价具有很重要的临床应用价值。

Objective： This study aims to investigate the patients with chronic kidney disease in the endogenous creatinine clearance rate （Ccr） , B type natriuretic peptide （BNP） and high-sensitivity troponin I （hs-cTnl） value and its relationship to predict the prognosis of patients. Methods： 96 patients with chronic kidney disease in our hospital were selected as research object, and 40 healthy persons were taken as control group. Examination of serum creatinine was performed by Abbott C16000 instrument （Cr） and the creatinine clearance rate （Ccr） was calculated. The concentration ofhs-cTnI and BNP was determined by Abbott 12000. Results： In patients with chronic kidney disease, the concentration of BNP increased while the Ccr decreased, and Hs-cTnI also increased. Both BNP and hs-cTnI increased at the same time, which has important clinical value in the prognosis evaluation of patients.