摘要
This review reports some recent advances on the use of dendrimer-based systems for cancer therapy. Dendrimers are emerging as promising carriers or stabilizers for drugs and nanoparticles（NPs） due to their highly branched 3-dimensional globular shape, internal hydrophobic cavity and multiple peripheral functional groups. The fabricated nanoplatforms loaded with therapeutic agents such as drugs,siRNAs or NPs can be further modified to have targeting specificity, antifouling properties and good biocompatibility.In particular, recent advances in the surface modifications of dendrimers and the application of dendrimers as versatile platforms for different therapeutic treatments to cancer including chemotherapy, radiotherapy, photothermal therapy,photodynamic therapy, gene therapy, and combination therapy will be introduced in detail.
本文综述了一些基于树状大分子体系应用于癌症治疗的研究进展.树状大分子拥有高度支化的三维球状结构、内部疏水空腔以及多种表面功能基团,因而可以作为药物和纳米颗粒的载体或者稳定剂.装载了治疗试剂(如药物、siRNA或者纳米颗粒)的纳米平台可进一步被修饰而获得靶向特异性、抗污性能和良好的生物相容性.本文详细介绍了树状大分子表面修饰并作为多功能平台应用于对癌症的不同治疗手段的进展,包括:化疗、放疗、光热治疗、光动力治疗、基因治疗以及联合治疗.
作者
Zhijuan Xiong
Mingwu Shen
Xiangyang Shi
熊智娟;沈明武;史向阳(State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology,Donghua University)
基金
financially supported by the Fundamental Research Funds for the Central Universities (for Shi X, Xiong Z, and Shen M)
the Science and Technology Commission of Shanghai Municipality (15520711400 and 17540712000)
the National Natural Science Foundation of China (81761148028 and 21773026)
