盐酸氨溴索对慢性阻塞性肺疾病患者免疫功能及炎症因子的影响

The Effect of Ambroxol Hydrochloride for Immune Function and Inflammatory Factors in Patients with Chronic Obstructive Pulmonary Disease

目的:探讨盐酸氨溴索对慢性阻塞性肺疾病(COPD)患者免疫功能及炎症因子的影响。方法:将2014年6月～2016年6月遂宁市中心医院收治的88例COPD患者随机分成对照组和观察组各44例。患者均先给予常规治疗,对照组再给予福莫特罗复方干粉吸入剂吸入治疗,而观察组给予盐酸氨溴索静脉滴注进行治疗,经过14 d治疗后评价患者的治疗疗效,对比两组患者治疗前后的肺功能指标、免疫功能指标及炎症因子。结果:观察组总有效率(90.91%)显著高于对照组(75.00%)(P<0.05)。两组患者治疗后用力肺活量(FVC)、第一秒用力呼气量(FEV1)、最大呼气峰流速值(PEF)均升高,且观察组升高更明显,差异有统计学意义(P<0.05);两组患者治疗后CD3^+、CD4^+、CD4^+/CD8^+比值均升高,同时CD8^+降低,但观察组优于对照组(P<0.05)。治疗后两组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平均降低,且观察组血清TNF-α、IL-6水平均明显低于对照组(P<0.05)。结论:盐酸氨溴索可改善COPD患者的肺功能、增强免疫功能,降低炎症因子水平,进而提高治疗效果。

Objective：To explore the effect of ambroxol hydrochloride for immune function and inflammatory factors in patients with COPD.Methods：88 patients with COPD in Suining Central Hospital from June 2014 to June 2016 were randomly divided into control group and observation group,each group with 44 cases.On the base of conventional therapy,the control group applied to symbicort turbuhaler inhalation therapy,and the observation group received ambroxol intravenous injection therapy.The therapeutic effect was evaluated After 14 days of treatment.Compared the lung function index,immune function index and inflammatory factors of two groups before and after treatment.Results：The total effective rate of the observation group（90.91%） was significantly higher than that of the control group（75.00%）（P〈0.05）.After the treatment,the FVC,FEV1,PEF of two groups were increased,and the observation group increased significantly,the difference was statistically significant（P〈0.05）.Two groups of CD3＋,CD4＋,CD4＋/CD8＋ratio were increased,while the CD8＋were reduced,but the amplitude change of observation group was significantly higher than the control group（P〈0.05）.After treatment,the serum levels of TNF-α and IL-6 in the two groups were decreased,and the serum TNF-α and IL-6 water in the observation group were significantly lower than those of the control group（P〈0.05）.Conclusion：Ambroxol hydrochloride can improve lung function,enhance immune function,reduce inflammatory factors,and improve therapeutic effect in patients with COPD.