老年原发性高血压患者血清SF、hs-CRP、Hcy、Cys C水平及血脂指标与颈动脉内膜中层厚度的相关性研究

Correlation Study of Serum SF, hs-CRP,Hcy,and Cys C Levels and Blood Lipid Indexes with Carotid Intima Media Thickness in Elderly Patients with Essential Hypertension

目的:研究老年原发性高血压(EH)患者血清铁蛋白(SF)、超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、胱抑素C(Cys C)水平及血脂指标与颈动脉内膜中层厚度(IMT)的相关性。方法:选择从2016年6月到2018年1月在广州军区广州总医院心血管内科接受治疗的100例老年EH患者作为研究对象。根据颈动脉的IMT值将患者分为斑块形成组(IMT≥1.3 mm)30例、IMT增厚组(1.0 mm<IMT<1.3 mm)42例、IMT正常组(IMT≤1.0 mm)28例,对比各组血脂指标以及血清SF、hs-CRP、Hcy、Cys C水平,分析IMT与血脂指标及SF、hs-CRP、Hcy、Cys C的相关性,并分析IMT增厚的危险因素。结果:斑块形成组和IMT增厚组的总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)水平明显高于IMT正常组(P<0.05),且斑块形成组又高于IMT增厚组(P<0.05)。斑块形成组和IMT增厚组的血清SF、hs-CRP、Hcy及Cys C水平明显高于IMT正常组(P<0.05),且斑块形成组又高于IMT增厚组(P<0.05)。根据Spearman相关性分析显示,老年EH患者IMT与SF、hs-CRP、Hcy、Cys C、TC及LDL-C均呈正相关(P<0.05)。根据Logistic回归分析结果显示,SF、hs-CRP、Hcy、Cys C均是老年EH患者IMT增厚的危险因素(P<0.05)。结论:血脂指标中TC、LDL-C及血清SF、hs-CRP、Hcy、Cys C水平与老年EH患者颈动脉IMT密切相关,且SF、hs-CRP、Hcy、Cys C是IMT增厚的危险因素。

Objective： To investigate the correlation between serum ferritin（SF）, high sensitivity C reactive protein（hs-CRP）,homocysteine（Hcy） and cystatin C（Cys C） and blood lipid indexes with carotid intima media thickness（IMT） in elderly patients with essential hypertension（EN）. Methods： 100 elderly patients with EH who were treated in our hospital from June 2016 to March 2018 were selected as the subjects. According to the IMT value of carotid artery, the patients were divided into plaque formation group（IMT1.3 mm） with 30 cases, IMT thickening group（1.0 mmIMT1.3 mm） with 42 cases, IMT normal group（IMT=1.0 mm） with 28 cases.Blood lipid indexes levels, serum SF, hs-CRP, Hcy and Cys C levels in each group were compared. The correlation between IMT and blood lipids indexes, SF, hs-CRP, Hcy and Cys C were analyzed. Results： The levels of total cholesterol（TC） and low density lipoprotein cholesterol（LDL-C） in the plaque formation group and the IMT thickening group were significantly higher than those in the IMT normal group, and the plaque formation group was higher than the IMT thickening group（P0.05）. The levels of serum SF, hs-CRP, Hcy and Cys C in plaque formation group and IMT thickening group were significantly higher than those in IMT normal group, and plaque formation group was higher than that in IMT thickening group（P0.05）. According to Spearman correlation analysis showed that IMT in elderly patients with EH was positively correlated with SF, hs-CRP, Hcy, Cys C, TC and LDL-C（P0.05）. According to the result of Logistic regression analysis showed that SF, hs-CRP, Hcy and Cys C were all risk factors for IMT thickening in elderly patients with EH（P0.05）. Conclusion： The levels of TC, LDL-C and serum SF, hs-CRP, Hcy and Cys C were closely related to the carotid IMT in elderly EH patients, and SF, hs-CRP, Hcy and Cys were the risk factors for IMT thickening.