IMP3-肾细胞癌患者转移风险和预后的独立预测因子

IMP3-the independent predicting factor for metastasis and prognosis of patients with renal cell carcinoma

对肾细胞癌患者远处转移风险和预后进行相对精确的评估目前仍是肾细胞癌研究领域的重点和难点。胰岛素样生长因子RNA结合蛋白IMP3预测肾细胞癌患者转移风险和预后的价值已受到广泛关注,其在促进肾细胞癌侵袭转移中发挥的作用及其机制也被逐渐揭示。本文对有关IMP3在预测肾细胞癌患者转移风险和预后的作用,以及促进转移机制的研究进行回顾和总结,并对未来相关研究方向提出设想。

It’s difficult to make a relatively accurate assessment of the risk of distant metastasis and the prognosis of patients with renal cell carcinoma（RCC）,which remains the focus in the field of RCC studies.IMP3,an insulin-like growth factor mRNA binding protein,is valued because of its role in predicting the risk of metastasis and prognosis of RCC patients.Its role in promoting invasion and metastasis of RCC and the associated mechanism are gradually revealed.We will make a review and summary of the studies about the role of IMP3 in predicting metastatic risk and the prognosis of RCC patients.Meanwhile,we will propose our prospective reaserch directions.