乙肝病毒感染者血清前S1抗原检测及临床意义

Clinical Significance and Determinations of PreS1 Antigen in Patients with Hepatitis B

目的 探讨前 S1抗原与乙型肝炎病毒的存在关系。方法 采用 ELISA检测 42 0例乙型肝炎病毒感染者血清中的前 S1抗原。结果 在 1 48例 HBe Ag阳性标本中前 S1抗原阳性的 1 1 5例 ,阳性率77.7% ;1 99例 HBe Ag阴性而 Anti- HBe阳性的标本中前 S1抗原阳性的 1 0 1例 ,阳性率 5 0 .8% ;80例HBe Ag和 Anti- HBe均阴性的血清中前 S1抗原阳性的仅 1 9例 ,阳性率 2 3.8%。前 S1抗原在血清学表达上与 HBe Ag的阳性符合率高达 77.7%。结论 血清前 S1抗原是 HBV在体内复制的可靠标志 。

Objectives:To discuss the relationship between PreS1 and hepatitis B virus.Methods The adoption ELISA determines the PreS1 with 420 cases of the patients of hepatitis B virus infected in serum.Results The 115 cases of PreS1 antigen positive were found in 148 HBeAg positive patients to be of positive rate was 77 7%,and 101 cases of ones in 199 cases HBeAg negative with Anti HBe positive.Its preS1 positive rate was 50 8%.Only 19 cases were found in serum of the patiens that HBeAg and Anti HBe both were negative.The PreS1 antigen match the rate with HBeAg on the serum learn to express high amount to 77 7%.Conclusions PreS1 is the relicable marker of hepatitis B virus.The relations between PreS1 and the existance of hepatitis B virus are rather close.