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冠心病中医辨证分型与前列腺素、血小板功能、蛋白C抗原的关系 被引量:22

Relationship of Coronary Heart Disease Based on TCM Syndrome Differentiation and Prostaglandin,Blood Platelet Function,Protein C
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摘要 对68例冠心病心绞痛患者检测前列腺素、血小板功能和血浆抗凝蛋白 C、蛋白 S 后发现,患者血栓素B_2(TXB_2),β-血小板球蛋白(βTG),血小板第4因子(PF_4)显著增高,6-酮前列环素(6-keto-PGF_(1a))降低。血瘀证与气证(气虚气滞为主)比较,30例血瘀证以 TXB_2增高为主,βTG、PF_4值高,蛋白 C 抗原(PC:Ag)降低,38例气证以6-keto-PGF_(1a)降低为主,βTG,PF_4增高没有血瘀证明显,PC:Ag代偿性增高。这些结果有助于阐明冠心病心绞痛中医辨证分型的内在本质。 The relationship between 68 cases of thromboxane B_2(TXB_2),6-keto-prostaglandin F_(1a)(6-K -PGF_(1a)),β-thromboglobulin(βTG),platelet factor 4(PF_4),protein C antigen(PC:Ag),total-proteins (T-Ps)with coronary heart disease(CHD)based on TCM syndrome differentiation were studied.45 Cases of male,23 cases of female,they were divided into 30 cases of blood stasis group and 38 cases of Qi(气)syndrome group.39 healthy subjects of same age and sex were chosen as the control group. The results were as follows:The TXB_2,βTG,PF_4 in CHD were higher than those of control.6-K -PGF_(1a)was lower(P<0.05,P<0.01)respectively.The TXB_2 in blood stasis was significantly higher than that of Qi syndrome while the 6-K-PGF_(1a) in Qi Syndrome was significantly lower than that of blood stasis syndrome(P<0.01).The PC:Ag,T-Ps in CHD were higher than those of the control.The PC:Ag in blood stasis was lower and was higher in Qi syndrome(P<0.01).It showed that microth- rombosis formed in blood stasis group caused blood flow sIowly,while coronary-pathy and/or coronary spasm were the major pathologic change in Qi syndrome.Elevated PC:Ag,T-Ps in Qi syndrome showed that there were complementary action to hypercoagulation in Qi syndrome to eliminate coaghlation factor to prevent coagulation happening and stimulation of fibrinolysin activator,promoting fibrinogenolysis.As a result of improving coronary blood flow,angina pectoris disappeared.So no signs of blood stasis happened in Qi syndrome.Decreased PC:Ag,T-Ps in blood stasis group showed that there was failure of complementary action to hypercoagulation.Thus the signs of blood stasis were apparent,further developing acute myocardial infarction.In conclusion, βTG,PF_4,PC:Ag are indicators of CHD based on syndrome differentiation.
出处 《中西医结合杂志》 CSCD 北大核心 1991年第5期263-264,共2页
关键词 冠心病 辨证分型 前列腺素 syndrome differentiation prostaglandin platelet function protein-C
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