复发性口疮和口腔扁平苔藓与体液免疫功能的关系

A study on humoral immunity function in recurrent aphthous ulceration and in oral lichen planus

目的 :检测复发性口疮 (RAU)与口腔扁平苔藓 (OL P)患者体液免疫功能 ,探讨两病的病因及发病机理。 方法 :对 2 0例 RAU患者及 17例 OL P患者采用免疫比浊法测定血清 Ig G、Ig A、Ig M及补体 C3、C4 含量 ,并与标准值比较。 结果 :RAU患者血清 Ig A含量明显增高 (P <0 .0 1) ,其余指标无明显变化 (P>0 .0 5 ) ,OL P患者各测定指标均无明显变化 (P >0 .0 5 )。 结论:RAU的发生可能与机体体液免疫功能紊乱有关 ,特别是与血清 Ig A含量升高及其引起的细胞溶解有关。 OL

Objective: To explore the etiology and pathogenesis of recurrent aphthous ulceration(RAU) and oral lichen planus(OLP) by examination on the humoral immunity function. Methods: 20 RAU patients and 17 OLP patients were enrolled in this study. The total concentrations of IgG?IgA?IgM?C\-3 and C\-4 in serum were tested by immunonephelomytry. Results: The total concentrations of IgA in serum of RAU patients were obviously higher than that of the standard value (P<0.01), whereas other data were not significantly changed (P>0.05). There was no significant changes of all the data in OLP group (P> 0.05). Conclusion: The disorder of humoral immunity function,paticularly the increase of the total concentration of IgA in serum and its cytolysis may be related to the pathogenesis of RAU, while it may not be related to that of OLP.