甘露聚糖肽联合斑蝥酸钠维生素B_6治疗恶性胸腔积液的临床疗效观察

Clinical observation of Mannopeptide Combined with Sodium Cantharidate Vitamin B_6 in Treatment of Malignant Pleural Effusion

目的评价采用甘露聚糖肽联合斑蝥酸钠维生素B_6治疗恶性胸腔积液患者的效果。方法选取承德市中心医院2016年4月至2017年4月收治恶性胸腔积液42例患者,按入院先后顺序分为实验组和对照组,每组21例。实验组采用甘露聚糖肽+斑蝥酸钠维生素B_6治疗,对照组采用斑蝥酸钠维生素B_6治疗,对实验组和对照组的临床疗效及安全进行观察。结果实验组的治疗总有效率为80.95%,显著高于对照组(52.38%,P <0.05)。两组患者不良反应发生率比较差异无统计学意义(P> 0.05)。实验组KPS评分显著高于对照组(P <0.05)。结论恶性胸腔积液患者采用甘露聚糖肽+斑蝥酸钠维生素B_6治疗,可达到较好地临床效果,并可显著改善患者生存质量。

Objective To evaluate the effect of mannopeptide combined with cantharidate sodium vitamin B6 on patients with malignant pleural effusion.Methods Forty-two patients with malignant pleural effusion admitted to Chengde Central Hospital from April 2016 to April 2017 were divided into experimental group and control group according to the order of admission,21 cases in each group.The experimental group was treated with mannopeptide combined with cantharidate sodium vitamin B6,and the control group was treated with cantharidate sodium vitamin B6.The clinical efficacy and safety of the experimental group and the reference group were observed.Results The total effective rate of the experimental group was 80.95%,significantly higher than that of the control group(52.38%,P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The KPS score of the experimental group was significantly higher than that of the control group(P<0.05).Conclusion In the treatment of malignant pleural effusion,the use of mannan peptide combined with sodium cantharidin and vitamin B6 can achieve better clinical effect and improve the quality of life of patients.