加味四逆散治疗慢性布鲁氏菌病的临床与实验研究

Clinical and Experimental Studies of Supplemented Sini San in Treating Chronic Brucellosis

观察加味四逆散治疗慢性布鲁氏菌病（简称布病）的疗效。方法：用加味四逆散治疗慢性布病７６例（治疗组），同时与用穿山龙散治疗５１例（对照组）作对照观察，并进行动物实验。结果：近期疗效：治疗组总有效率和愈显率（９８．７％和９２．１％）优于对照组（８２．４％和４１．２％，Ｐ＜０．０１）；远期疗效：治疗组总有效率和愈显率（９８．７％和９０．８％）明显优于对照组（５１．０％和２１．６％，Ｐ＜０．０１）。实验研究表明，加味四逆散有明显的抑菌、调节免疫作用。结论：加味四逆散可提高慢性布病的远期疗效。

Abstract: To observe the effect of supplemented Sini San (SSNS) in treating chronic Brucellosis (CB).Methods: One hundred and twenty-seven patients were randomly divided into two groups, 76 cases in the treatment group were treated with SSNS and 51 cases in the control group treated with Dioscorea Nipponica Power. The effect of SSNS on mice model of CB was also observed simultaneously. Results: The short-term effects were that the total effective rate and markedly effective rate of the treatment were 98. 7% and 92. 1%, which were better than those of the control group (82. 4 % and 41. 2 % )respectively, P＜0. 01. The long-term follow-up result of the treatment group also showed its superiority to the control group, the total effective rates of the two groups were 98. 7% and51. 0 %, and the markedly effective rates were 90. 8% and 21. 6% respectively (P＜0. 01 ). Animalexperiments indicated SSNS has obvious effect of antibiotics and immunomodulation. Conclusion: SSNS was effective in treating CB, including the long-term follow-up result.Keywoeds:Supplemented Sini San, chronic Brucellosis, long-term follow-up result