PLGA-PEG-PLGA温敏水凝胶的制备及其流变学研究

Synthesis and the Rheology Research of PLGA-PEG-PLGA Thermosensitive Hydrogel

目的:合成不同的PLGA-PEG-PLGA温敏水凝胶,并研究水凝胶相变温度及流变学与原料比例的关系。方法:以混旋丙交酯(DLlactide)、乙交酯(Glycolide)和PEG为原料,异辛酸亚锡为催化剂,采用开环聚合法,通过改变投料配比和PEG的分子量,制备PLGA-PEGPLGA嵌段共聚物。倒转试管法测定共聚物水溶液的相变温度和沉淀温度;同时用Anton Paar MCR301对水凝胶流变学进行研究。结果:原料比例不同,合成的水凝胶流变学参数和相变温度也不同。结论:改变聚乙二醇的分子量和丙交酯与乙交酯的比例来控制合成共聚物的流变学参数以及相变温度,也可以通过改变共聚物的浓度来小范围地调节其流变学参数和相变温度。

Objective: To synthesize the different thermosensitive PLGA-PEG-PLGA copolymers, and investigate the relation between the phasetransition temperature, dynamic rheological measurements of the copolymers and ratio of raw materials. Methods: The triblock copolymers PLGAPEG-PLGA were synthesized by ring-opening polymerization of D, L-lactide and glycolide with polyethylene glycol (PEG) in the presence ofstannous octoate. A single test-tube inverting method was employed to determine the phase transition temperature; the Anton Paar MCR301wereemployed to investigate dynamic rheological. Result: If the ratio of ingredient was different, the phase transition temperature and dynamic rheologicalwere different too. Conclusion: We can control the phase transition temperature and dynamic rheological of the copolymers by change the molecularweight of PEG, the ratio of polymerization of D, L-lactide and glycolide used and the concentrations of the copolymers.