缺血性卒中后抑郁患者静息状态下默认网络功能连接的研究

Resting-state functional magnetic resonance imaging study of ischemic post stroke depression

目的利用静息态功能磁共振成像(resting-state functional magnetic r e s o n a n c e i m a g i n g,r s-f M R I)技术,研究缺血性卒中后抑郁(p o s t s t r o k e depression,PSD)患者静息状态下默认网络(default mode network,DMN)功能连接的变化。材料与方法选取13例发病在两周内、汉密尔顿抑郁量表(hamilton depression scale,HAMD)评分>7分且为首发抑郁的PSD患者,同时选择13名正常被试作为对照组(control)分别进行静息态f MRI扫描。分别选取双侧楔前叶作为感兴趣区(region of interest,ROI),计算并比较两组被试默认网络功能连接的变化。结果与正常被试相比,PSD患者双侧顶下小叶、双侧额颞叶与右侧楔前叶功能连接减低;右侧顶下小叶、双侧额颞叶与左侧楔前叶功能连接减低,而未发现功能连接显著增高的脑区。结论默认网络功能连接的变化可能与卒中后抑郁的发生具有相关性。

Objective:To investigate the altered functional connectivity(FC)ofthe default mode network(DMN)in patients with post ischemic stroke depression.Materials and Methods:Thirteen PSD patients and13matched normal controls wererecruited and the resting-state fMRI images were acquired on a3.0T Siemens MRIscanner.The datasets were analyzed using SPM8and REST.The bilateral precuneuswere selected as regions of interest(ROIs),and functional connectivity was calculatedand compared between PSD patients and normal controls.Results:The FCs of theDMN was altered in PSD patients compared to normal controls.The brain areas whichshowed decreased FCs including the bilateral inferior parietal lobule,bilateral frontallobule and bilateral temporal lobule.However,the increased FC has not been found inthe current study.Conclusion:Dysfunction of the DMN may be associated with thedevelopment of PSD.