Klk6、Her-2蛋白及Ki-67在子宫内膜癌中的表达及临床病理意义

Expression of Klk6, Her-2 protein and Ki-67 in endometrial carcinoma and their clinicopathological significance

目的探讨组织型激肽释放酶6(Klk6)、Her-2蛋白及Ki-67在子宫内膜癌中表达的意义。方法应用免疫组化检测正常增生期内膜、单纯性增生性内膜、复杂性不典型增生性内膜各19例和子宫内膜样腺癌38例中Klk6、Her-2蛋白、Ki-67的表达情况。利用统计学软件SPSS 17.0和Graphpad Prism 5进行统计学分析检测并探讨其意义。结果 Klk6、Her-2蛋白、Ki-67在癌组织中表达高于其他病变(P<0.05),Klk6在不同肿瘤临床分期中表达有明显统计学差异(P<0.05);而Klk6、Her-2蛋白在子宫内膜癌分级及淋巴结有无转移表达无统计学差异(P>0.05)。结论 Klk6、Her-2蛋白、Ki-67在子宫内膜癌中的表达与肿瘤发生有一定的相关性,特别是Klk6与子宫内膜癌分期相关,对临床诊断、治疗及评估预后具有一定的价值。

Objective To investigate the significance of expression of tissue-specific kallikrein6(Klk6),Her-2protein and Ki-67in endometrial carcinoma.Methods Immunohistochemistry was used to detect the expression of Klk6,Her-2protein and Ki-67in normal proliferative endometrium(n=19),simple proliferative endometrium(n=19),complex atypical hyperplastic endometrium(n=19)and endometrioid adenocarcinoma(n=38).Statistical software SPSS17.0and Graphpad Prism5were used to detect and explore its significance.Results The expression of Klk6,Her-2protein and Ki-67in cancer tissues was higher than that in other lesions(P<0.05).There was statistically significant difference in the Klk6expression among different clinical stages(P<0.05).There was no significant difference in the expression of Klk6and Her-2protein among different grades of endometrial carcinoma or in endometrial carcinoma with or without lymph node metastasis(P>0.05).Conclusion The expression of Klk6,Her-2protein and Ki-67has some correlation with the occurrence of endometrial carcinoma,and has certain value for clinical diagnosis,treatment and prognosis evaluation,of which especially Klk6is associated with staging of endometrial cancer.