不同促排卵方式对人工授精后妊娠结局的影响

Influence of different ovarian hyper-stimulation methods on pregnancy outcome after intrauterine insemination

目的探讨不同促排卵方式对人工授精后妊娠结局的影响。方法对167例接受人工授精的患者及配偶的临床资料进行回顾性分析,根据促排卵方式不同,将研究对象分为来曲唑组(n=79)和克罗米芬组(n=88)。比较两组患者的性激素水平、窦卵泡数及妊娠结局。结果两组患者E、FSH、LH、T水平、窦卵泡数、活产率、自然流产率及临床总妊娠率比较,差异无统计学意义(P>0.05)。两组患者第1~4周期妊娠率、多胎妊娠率及异位妊娠率比较,差异有统计学意义(P<0.05)。结论在促排卵药物选择中,来曲唑比克罗米芬更适合应用于人工授精治疗。

Objective To investigate the effects of different ovarian hyper-stimulation methods on pregnancy outcome after intrauterine insemination.Methods The clinical data of 167 patients with intrauterine insemination and their spouses were retrospectively analyzed.All the patients were divided into letrozole group(n=79)and clmiphene citrateclinical group(n=88)according to the different ovarian hyper-stimulation drugs.The sex hormone levels,number of antral follicles and pregnancy outcomes were compared between the two groups.Results There were no significant differences in levels of E,FSH,LH and T,number of antral follicles,live birth rate,natural abortion rate and clinical total pregnancy rate between the two groups(P>0.05).There were significant differences in pregnancy rate at 1-4 circle,multiple pregnancy rate and ectopic pregnancy rate(P<0.05).Conclusion Compared with clmiphene citrate,letrozole as the drug of ovarian hyper-stimulation on the process of intrauterine insemination has superiority.