广西地区健康体检人群液基薄层细胞学筛查宫颈病变的价值研究

Value of thinprep cytologic screening for cervical lesions in healthy population in Guangxi area

目的:利用液基薄层细胞学筛查广西地区健康体检人群筛查宫颈病变情况,为临床防治提供参考。方法:选取2014年3月至2016年3月7824例健康体检人群作为研究对象,均进行液基薄层细胞学检查,并将其结果和组织病理学结果进行比较。结果:液基薄层细胞共检测出宫颈阳性病变105例,占1.34%,且逐年升高;在分布上以ASC-US、LSIL、AGC-NOS发生率最高,分别占全部的33.33%、25.71%、17.14%,和其他比较差异显著(P<0.05);以组织病理学为标准,共检测出阳性数94例,液基薄层细胞符合率89.52%,两种方法结果比较差异无统计学意义(χ~2=1.012,P=0.092);组织病理学CINⅠ、CINⅡ、CINⅢ检出数分别为26、23、24例,随着病变程度加重,两种相对危险度均逐渐升高。结论:液基薄层细胞学筛查能早期发现宫颈病变,结合组织病理学对宫颈癌早期防治和干预有重要价值。

Objectives:To observe the clinical value of thinprep cytologic screening for cervical lesions in healthy people in Guangxi area.Methods:A total of 7824 healthy people from March 2014 to March 2016 were selected as the research objects.All the patients were examined by liquid based cytology.Results:ThinPrep cytology were detected positive cervical lesions in 105 cases,accounting for 1.34%,with an increase trend.In terms of distribution,ASC-US,LSIL and AGC-NOS had the highest incidence,accounted for 33.33%,25.71%,17.14%respectively,with significant difference from others(P<0.05).By histopathology,94 cases were detected positive,a coincidence rate of 89.52%with thinprep cytology,without significant difference between the two methods(X 2=1.012,P=0.092).According to the histopathology,there were 26,23,24 cases of CIN I and CIN II,CIN III and with the increasing of lesion severity,the two relative risk elevated gradually.Conclusion:Thinprep cytologic screening can detect cervical lesions early,which combined with histopathology has important value for early prevention and intervention of cervical cancer.