猪源Toll样受体家族(TLRs)及其在抗病育种中的应用

Advances in porcine Toll-like receptor family (TLRs) and its application in resistance breeding

Toll样受体(toll like receptors,TLRs)作为模式识别受体,不仅能够对机体特异性配体进行识别,并通过多种信号传导通路(由髓样分化蛋白88或由β-干扰素TLR结构域衔接蛋白介导)启动信号传导继而引发特异性的免疫应答,同时还在一些由支原体、病毒、细菌等感染引起的免疫应答过程中发挥了重要的调控功能。因为其重要的免疫调控作用,Toll样受体家族已成为近些年研究的热点,对畜禽抗病育种工作也具有重要的科学意义和应用前景。文章综述了猪源TLRs的种类、功能、遗传变异以及介导的信号通路,并重点介绍了猪源TLRs在抗病育种中的应用,旨在为猪Toll样受体家族基因功能研究及有效遗传标记的筛选提供参考依据。

Toll-like receptors(TLRs),as pattern recognition receptors,can not only recognize body s specific ligands and start signal transduction through a variety of signaling pathways(mediated by myeloid differentiation protein 88 or by the TLR domain protein of beta-interferon),which leads to specific immune responses,but also play important regulatory roles in some immune responses caused by mycoplasma,viruses,bacteria and other pathogens.Toll-like receptor family has become research hotspots in recent years because of its important immune regulations,which has important scientific significance and application prospect for the breeding of livestock and poultry.The types,functions,heritable variation and mediated signaling pathways of pig Toll-like receptor family were reviewed in this article,and the application of pig TLRs in disease resistance breeding was introduced intensively,which aimed to provide reference and basis for the research of gene function of pig Toll-like receptor family and screening effective genetic markers.