阿莫西林所致不良反应及药学临床分析

Analysis of Adverse Reactions and Clinical Pharmacy Caused by Amoxicillin

目的对应用阿莫西林引起的不良反应情况及相关药学进行分析,为临床合理用药提供指导。方法对2015年1月—2017年1月该院接治的85例阿莫西林不良反应患者的临床资料进行回顾性研究,分析和总结出现的不良反应原因。结果通过分析,给药1~7 d的不良反应发生率高于其他时间段,差异有统计意义(P<0.05),且口服用药占比为85.1%,高于静脉滴注用药的14.9%(P<0.05);过敏反应是最为主要的不良反应,占比为58.6%,其次为消化道不良反应、神经系不良反应等。结论阿莫西林是常用的光谱抗生素,但临床不良反应较多,应根据患者病情制定合理用药方案,确保用药安全、有效。

Objective This paper tries to investigate the adverse reactions caused by amoxicillin and related pharmacology and to provide guidance for the rational use of drugs.Methods The clinical data of 85 patients with amoxicillin adverse reactions from January 2015 to January 2017 were retrospectively studied,and the causes of adverse reactions were analyzed and summarized.Results According to the analysis,the incidence rate of adverse reaction of 1~7d was higher than that of other time periods,the difference was statistically significant(P<0.05),and the proportion of oral administration was 85.1%,which was higher than 14.9%of intravenous drip(P<0.05).Allergic reaction was the most important adverse reaction,accounting for 58.6%,followed by gastrointestinal adverse reactions,and neurological adverse reactions.Conclusion Amoxicillin is a commonly used spectroscopic antibiotic,but the clinical adverse reactions are relatively more than other medicine.The rational drug regimen should be developed according to the patient’s condition,so as to ensure the safety and effective drug use.