微生态制剂联合美沙拉嗪在溃疡性结肠炎治疗中的作用

Role of microbiological agents combined with mesalazine sustained-release granules in treatment of ulcerative colitis

目的研究微生态制剂联合美沙拉嗪在溃疡性结肠炎(UC)治疗中的作用。方法将126例UC患者随机分为两组,对照组口服美沙拉嗪缓释颗粒4g/d;联合组在对照组的基础上,口服枯草杆菌二联活菌肠溶胶囊500mg,3次/d。疗程1个月。监测患者治疗前后血红蛋白(HB)、白蛋白(ALB)、超敏C反应蛋白(hs-CRP)和红细胞沉降率(ESR)、白细胞介素(IL)-6、IL-10、血清钙结合蛋白S100A12水平。结果联合组总有效率高于对照组(P<0.01),与对照组比较,联合组治疗后ALB及IL-10增高(P<0.05),而hs-CRP、ESR、IL-6、血清S100A12水平均降低。结论微生态制剂能提高美沙拉嗪治疗UC的有效率,安全可靠。

Objective To study the role of microbiological agents combined with mesalazine in the treatment of ulcerative colitis(UC).Methods A total of 126 UC patients were enrolled amd randomly divided into two groups,and the control group was given 4 g/d of mesalazin sustained-release granules.On the basis of the control group.the combined group also took 500 mg of live combined bacillus subtilis and enterococcus faecium enteric-coated capsules 3 times per day for one month.The levels of hemoglobin(HB),albumin(ALB),hypersensitive C reactive protein(hs-CRP),erythrocyte sedimentation rate(ESR).interleukin(IL)-6,IL-10 and serum calcium binding protein were monitored before and after the treatment.Results The total effective rate in combined group was significantly higher than that of control group(P<0.01).Compared with control group,ALB and IL-10 witnessesd increases in combined group(P<0.05),while hs-CRP,ESR,IL-6 and serum S100A12 decreased.Conclusion Microbiological agents can improve the efficiency,safety and reliability of mesalazin in the treatment of UC.