马来酸氟伏沙明与阿米替林治疗脑卒中后抑郁的临床效果

Clinical Effect of Fluvoxamine Maleate plus Amitriptyline in Post-stroke Depression

目的:探讨脑卒中并发抑郁患者应用马来酸氟伏沙明联合阿米替林的临床治疗效果。方法:临床纳入笔者所在医院2014年7月-2016年7月收治的80例脑卒中并发抑郁患者为研究对象,按入院顺序分为两组,各40例。对照组采用马来酸氟伏沙明治疗,观察组采用马来酸氟伏沙明联合阿米替林治疗。观察两组治疗效果和患者抑郁情况。结果:观察组患者治疗总有效率高达97.50%,对照组患者治疗总有效率为82.50%,观察组治疗效果优于对照组,差异有统计学意义(χ~2=12.500,P<0.05);治疗前,两组患者汉密顿抑郁量表(HAMD)评分比较,差异无统计学意义(t=0.886,P=0.378),治疗后,观察组HAMD评分优于对照组,差异有统计学意义(t=22.758,P=0.000)。结论:脑卒中并发抑郁患者采用马来酸氟伏沙明联合阿米替林治疗,可明显改善患者的抑郁情况,提高治疗有效率。

Objective:To discuss the clinical effect of Fluvoxamine maleate plus Amitriptyline in stroke patients with depression.Method:A total of 80 stroke patients with depression treated from July 2014 to July 2016 in our hospital were selected.The subjects were assigned to control group and observation group according to the registration number,40 cases in each group.The control group patients took the Fluvoxamine Maleate alone,and the observation group used Fluvoxamine Maleate plus Amitriptyline.The therapeutic effect and depression symptoms were explored.Result:The total effective rate in the observation group was 97.50%,significantly higher than 82.50%in the control group,the difference was statistically significant(字2=12.500,P<0.05);before treatment,there was no statistically different of the Hamilton Depression Scale(HAMD)scores between the two groups(t=0.886,P=0.378);after treatment,the HAMD score in the observation group was better than that of the control group,the difference was statistically significant(t=22.758,P=0.000).Conclusion:The Fluvoxamine Maleate plus Amitriptyline can remarkably improve the depression symptoms and clinical effective rate.