早期血管性认知功能障碍生物标志物的研究进展

Advances in biomarkers of early vascular cognitive impairment

血管性认知功能障碍(vascular cognitive impairment,VCI)是指由脑血管疾病危险因素和脑血管疾病引起的一类认知功能损害综合征。VCI的发生、发展与脑血管疾病危险因素、糖脂代谢、甲状腺功能、慢性炎症和阿尔茨海默病(Alzheimer’s disease,AD)相关的β-淀粉样蛋白、tau蛋白等均相关,筛选VCI相关的有效的生物标志物并在VCI早期有效地控制其危险因素可能是延缓VCI患者认知功能下降和痴呆发生的关键。本文从代谢相关的生物标志物、炎症相关的生物标志物和AD相关的生物标志物这3个主要方面对近年来VCI相关的生物标志物的研究进展作一概要介绍。

Vascular cognitive impairment(VCI)is a type of cognitive impairment syndrome caused by cerebrovascular disease risk factors and cerebrovascular diseases.The occurrence and development of VCI are related to vascular risk factors,glycolipid metabolism,thyroid function,chronic inflammation,amyloidβ-protein and tau protein associated with Alzheimer’s disease(AD)and so on.Screening of effective biomarkers related to VCI and effective control of risk factors at the early stage of VCI may be the key to delay cognitive decline and reduce the risk of dementia.This article reviews the recent research progress in three major VCI-related biomarkers including metabolic biomarkers,inflammatory biomarkers and AD-related biomarkers.