清胰化积方联合顺铂治疗胰腺癌疗效及对TGF-β/smads信号通路的影响

The effect of Qingyi Huaji prescriptions combined with cisplatin on pancreatic cancer and the effect of TGF-β/smads signaling pathway

目的:探讨清胰化积方联合顺铂对胰腺癌的作用及对TGF-β/smads信号通路的影响。方法:对我院住院部80例胰腺癌患者回顾分析,按照随机表法分为两组,每组40例,对照组予单药顺铂治疗,观察组予清胰化积方联合顺铂治疗。结果:观察组总有效率45%、临床控制率77.5%均显著高于对照组32.5%、55%(χ~2=8.26,P<0.05)。观察组治疗后肾功能各指标均显著优于对照组(t=3.82、3.27、4.89、3.61,P<0.05)。观察组治疗前后PLT比较有显著差异(t=7.53,P<0.05),对照组治疗前后PLT、肝功能比较有显著差异(t=6.54、4.48,P<0.05)。两组比较,观察组肝功能治疗后异常上升显著低于对照组(t=4.71,P<0.05)。治疗后观察组CD_4^+及CD_4^+/CD_8^+的比值均高于对照组,CD_8^+低于对照组,有统计学差异(t=10.37、11.34、10.84,P<0.05)。两组患者Spitzer指数均显著高于治疗前(P<0.05),两组比较,观察组Spitzer指数显著高于对照组(P<0.05)。两组TGF-β表达均较前显著改善(P<0.05),且观察组BMP-Ⅱ受体水平显著降低于对照组(P<0.05)。两组Smads水平均较前显著改善(P<0.05),且观察组Smads水平均显著降低于对照组(P<0.05)。结论:清胰化积方联合顺铂治疗胰腺癌的临床疗效显著,能增强患者的免疫功能,改善患者生活质量,且安全性好,本法是通过调控TGF-β/smads信号通路发挥抗胰腺癌的效果。

Objective:To explore the effect of cisplatin on pancreatic cancer and the effect of TGF-beta/smads signaling pathway.Methods:80 cases of pancreatic cancer in our hospital were retrospectively analyzed.According to the treatment of patients,they were divided into two groups,40 cases in each group.The control group was treated with cisplatin,and the observation group was treated with Qingyi Huaji recipe plus cisplatin.Results:The total effective rate of the observation group was 45%,and the clinical control rate was 77.5%significantly higher than that of the control group was 32.5%、55%(χ2=8.26,P<0.05).Compared with the control group(t=3.82,3.27,4.89,3.61,P<0.05),all the indexes of renal function were significantly better than those of the control group.Observation group before and after treatment the WBC,liver function was no significant difference(t=0.75,1.09,P>0.05).The observation group PLT was more significant differences before and after the treatment(t=7.53,P<0.05).The control group before and after treatment of PLT,liver function was more significant difference(t=6.54,4.48,P<0.05),the control group before and after treatment the WBC there was no significant difference(t=0.87,P>0.87),comparing the two groups,observation group rising abnormal liver function after treatment was significantly lower than the control group(t=4.71,P<0.05).The observation group after treatment of CD 4+and CD 4+/CD 8+ratio were higher than the control group,CD 8+was lower than the control group,with statistical difference(t=10.37,11.34,10.84,P<0.05).In both groups,the Spitzer index was significantly higher than before treatment(P<0.05),and the observation group was significantly higher than the control group(P<0.05).The expression of TGF-beta in both groups was significantly improved(P<0.05),and the level of bmp-ii receptor in the observation group was significantly decreased in the control group(P<0.05).The level of Smads in both groups was significantly improved(P<0.05),and the level of Smads in the observation group was significantly lower than that in the control group(P<0.05).Conclusion:Qingyi Huaji prescriptions combined cisplatin in the treatment of pancreatic cancer clinical curative effect is distinct.It can enhance the immunity of the patients,improve patient quality of life,and good safety,may be through regulating the TGF-β/smads signal pathways play a role of resistance of pancreatic cancer.